Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic cigarette use

Brain Research Bulletin
Andréa L HobkirkStephen J Wilson

Abstract

Resting state functional brain connectivity (rsFC) may be an important neuromarker of smoking behavior. Prior research has shown, among cigarette smokers, that nicotine administration alters rsFC within frontal and parietal cortices involved in executive control, as well as striatal regions that drive reward processing. These changes in rsFC have been associated with reductions in withdrawal symptom severity. We currently have a limited understanding of how rsFC is affected by the use of electronic cigarettes (ecigs), an increasingly popular class of products, the members of which deliver nicotine with varying effectiveness. The current study used fMRI to determine the effects of ecig use on rsFC and withdrawal symptoms. Independent component, dual regression, and permutation analyses were conducted on rsFC collected from ecig users before and after an ecig use episode (n=9) that occurred after 14h of nicotine abstinence. Similar to the known effects of nicotine administration, ecig use decreased rsFC of two clusters in the right frontal pole and frontal medial cortex with an attentional control salience network, and decreased rsFC of five clusters in the left thalamus, insula, and brain stem with a reward network encompassing ...Continue Reading

Citations

Mar 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Joanna A RuszkiewiczMichael Aschner
Feb 23, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Sarah W YipChadi G Abdallah
Jun 28, 2020·Neuropharmacology·Asti JacksonSuchitra Krishnan-Sarin
Jun 28, 2021·Addiction Biology·Wei-Ran ZhouGuang-Heng Dong

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