Changes in retinal arbors in compressed projections to half tecta in goldfish

Journal of Neurobiology
J T Schmidt, T Coen

Abstract

In adult goldfish, electrophysiological studies have shown that the retinotectal projection reorganizes, following removal of half of the tectum, to form a complete but compressed projection over the remaining half tectum. As a result, each fiber terminates more rostrally than normal. Electron microscopic studies suggest a competition between retinal fibers for a fixed number of synaptic sites. The current study examines whether retinal arbors in the compressed projection are smaller than normal in extent or branching and whether the fiber paths in the tectum show the rostral movements and the search strategy that the retinal fibers use. The caudal half tectum was removed without cutting retinal fibers except those at the cut edge. At 3 to 19 months afterward, retinal fibers were labeled with horseradish peroxidase. In whole-mounted tecta, fibers and terminals were drawn under camera lucida and compared with normal arbors. The axonal paths were also traced across the tectum to their termination sites. At 3 to 6 months (early stages of compression), the arbors were rather normal in appearance, although they were actually significantly larger (23%) than normal in linear extent, arborized somewhat deeper and had fewer branches (18...Continue Reading

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Citations

Sep 19, 2012·International Wound Journal·Alexandros V KamaratosAndreas I Melidonis
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Sep 20, 2008·Physical Therapy·Jennifer S BrachAnne B Newman
Jan 26, 2017·Frontiers in Neural Circuits·Elena KutsarovaEdward S Ruthazer

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