Abstract
To describe the relationship of change in retinal vessel diameters to the subsequent 6-year incidence and progression of diabetic retinopathy (DR) and incidence of proliferative diabetic retinopathy (PDR) and macular edema (ME) in persons with diabetes mellitus. A total of 1098 persons with diabetes who had DR graded from fundus photographs and had computer-assisted measurements of the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent(CRVE) participated in examinations in 1980-1982, 1984-1986, and 1990-1992. During the first 4-year period, the mean change in CRAE and CRVE was −0.37 and 2.54 μm, respectively.The 6-year incidence and progression of DR and the incidence of PDR and ME from 1984-1986 to 1990-1992 were 56%, 39%, 15%, and 11%, respectively. In multivariate analyses, while controlling for duration, diabetes type, and other factors, an increase of 10 μm in CRVE from 1980-1982 to 1984-1986 was associated with increases in the 6-year incidence of DR (odds ratio [OR],1.26; 95% CI, 1.10-1.43), progression of DR (OR, 1.21;95% CI, 1.12-1.30), incidence of PDR (OR, 1.19; 95%CI, 1.07-1.32), and incidence of ME (OR, 1.16; 95% CI,1.03-1.31). No interactions of these associations by diabetes type ...Continue Reading
References
Jan 1, 1975·The British Journal of Ophthalmology·A GarnerC T Dollery
Jun 1, 1976·Preventive Medicine
Sep 19, 1992·BMJ : British Medical Journal·V PatelE Kohner
May 1, 1991·Ophthalmology
May 1, 1991·Ophthalmology
Jul 1, 1990·Ophthalmology·R T MeehanA Cymerman
Dec 1, 1985·Archives of Ophthalmology
Feb 1, 1989·Archives of Ophthalmology·R KleinD L DeMets
Jul 1, 1986·Archives of Ophthalmology·J E GrunwaldB L Petrig
Sep 1, 1986·Ophthalmology·R KleinM D Davis
Jan 1, 1988·Journal of Clinical Epidemiology·S E MossE S Shrago
Apr 1, 1984·Archives of Ophthalmology·R KleinD L DeMets
Sep 1, 1994·Archives of Ophthalmology·R KleinK J Cruickshanks
Oct 27, 1998·Ophthalmology·R KleinK J Cruickshanks
Aug 3, 1999·American Journal of Epidemiology·A R SharrettR Klein
Nov 24, 1999·Archives of Ophthalmology·R KleinK J Cruickshanks
Dec 22, 1999·Ophthalmology·L D HubbardJ Cai
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R KleinG Evans
Sep 25, 2003·Journal of Clinical Epidemiology·Lloyd E ChamblessF Javier Nieto
Oct 17, 2003·Current Eye Research·Michael D KnudtsonBarbara E K Klein
Jan 14, 2004·Archives of Ophthalmology·Ronald KleinMari Palta
Sep 29, 2004·Archives of Internal Medicine·Barbara E K KleinJennifer O Reinke
Jul 11, 2006·Ophthalmology·Ekaterina AlibrahimTien Y Wong
Jul 13, 2006·Archives of Internal Medicine·Aaron R FolsomA Richey Sharrett
Jun 2, 2007·Ophthalmology·Ronald KleinTien Y Wong
Jun 15, 2007·Statistics in Medicine·Michael J PencinaRamachandran S Vasan
Jun 5, 2008·Diabetes Care·Ning CheungTien Yin Wong
Nov 26, 2008·Archives of Internal Medicine·Kevin McGeechanTien Y Wong
Dec 11, 2008·Ophthalmology·Ronald KleinBarbara E K Klein
Jan 12, 2011·Archives of Ophthalmology·Monique S RoyMalvin N Janal
Jan 12, 2011·Archives of Ophthalmology·Tien Yin Wong
Citations
Jun 18, 2014·The British Journal of Radiology·T J MacGillivrayE J R van Beek
Feb 23, 2013·Diabetes Care·M Kamran IkramUNKNOWN NIH/JDRF Workshop on Retinal Biomarker for Diabetes Group
Aug 25, 2015·Progress in Retinal and Eye Research·Alan W StittNoemi Lois
Jul 7, 2015·Acta Ophthalmologica·Oliver N KlefterMichael Larsen
Sep 21, 2015·Journal of Optometry·Rebekka HeitmarRobert P Cubbidge
Sep 28, 2015·The American Journal of Cardiology·Juan E GrunwaldUNKNOWN CRIC Study Investigators
Jan 24, 2015·Acta Ophthalmologica·Gerald LiewCatherine A Egan
Mar 13, 2014·Clinical & Experimental Ophthalmology·Mohamed DiraniPeter van Wijngaarden
Aug 13, 2013·Journal of Diabetes Research·Myra PoonKim C Donaghue
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Cheng-Hung LeeYi-Chang Su
Jun 4, 2014·Current Eye Research·Doreen SchmidlAlina Popa-Cherecheanu
Nov 16, 2013·Ophthalmic Epidemiology·Charles D McCannaBarbara E K Klein
Apr 30, 2016·Acta Ophthalmologica·Oliver Niels KlefterMichael Larsen
Jun 2, 2015·PloS One·Yong ChengXiaoxin Li
Oct 28, 2014·PloS One·Jie XuWen Bin Wei
Jan 30, 2016·The British Journal of Ophthalmology·Xiufen YangRonald P Danis
May 7, 2016·Clinical & Experimental Ophthalmology·Alexander R NewmanRobert J Casson
Oct 18, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ae Ra KeeLing-Jun Li
Dec 2, 2017·Clinical & Experimental Ophthalmology·Alexander NewmanRobert Casson
Feb 22, 2017·Journal of Medical Imaging·Sven HolmNiall McLoughlin
Aug 26, 2014·Eye·A MoradiQ D Nguyen
May 22, 2019·Investigative Ophthalmology & Visual Science·Jakob GrauslundUNKNOWN EUROCONDOR
Oct 28, 2019·Acta Ophthalmologica·Søren L BlindbaekJakob Grauslund
Jun 17, 2020·Clinical Science·Uwe QuerfeldAxel Radlach Pries
Sep 17, 2020·The British Journal of Ophthalmology·Luisa FrizzieroEdoardo Midena
Apr 21, 2016·BMC Ophthalmology·Yanmin DongQianying Gao
Mar 30, 2018·Frontiers in Neurology·Nai-Ching ChenYao-Chung Chuang
Mar 15, 2013·Clinical Science·Alan W StittTimothy M Curtis
Jul 21, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Zhong LinYuan Bo Liang
Jan 9, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jianqin LeiNizar Saleh Abdelfattah
Jul 30, 2019·Retina·Wenying FanMichael Ip
Mar 16, 2013·Retina·Marco LombardoGiuseppe Lombardo
Sep 22, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Rebekka HeitmarVikramjit Panesar
Jan 31, 2021·Diabetologia·Rachel B ForsterUNKNOWN Edinburgh Type 2 Diabetes Study (ET2DS) investigators
Oct 31, 2017·Journal of Hypertension·Kyoko Kawashima-KumagaiUNKNOWN Nagahama Study group
Aug 31, 2016·International Ophthalmology Clinics·Salman SarwarYasir J Sepah
May 22, 2018·Ophthalmology·Ronald KleinBarbara E K Klein
Mar 30, 2021·Topics in Stroke Rehabilitation·Ryan R Bailey, Molly Conroy
Jul 2, 2021·Computer Methods and Programs in Biomedicine·Maciej Czepita, Anna Fabijańska
Jan 17, 2019·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Galina Dimitrova, Etsuo Chihara