Changes in sensitivity to operant effects of dopaminergic and cholinergic agents following morphine withdrawal in rats

European Journal of Pharmacology
S D Glick, R D Cox

Abstract

Rats trained to bar-press on either a FI 15 sec or FR 30 schedule for water reinforcement were administered various doses of appomorphine, haloperidol, pilocarpine and scopolamine both before and 1--4 months after a 3-day period of continuous morphine administration. All drugs monotonically depressed response rates on both schedules with increasing dose. Chronic morphrine administration produced a persistent increase in sensitivity to apomorphine and pilocarpine and a persistent decrease in sensitivity to haloperidol and scopolamine. The results suggest that both dopaminergic and cholinergic supersensitivity are likely to be involved in protracted abstinence phenomena.

References

Sep 1, 1976·European Journal of Pharmacology·J P GreenP I Szilagyi

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Citations

Sep 1, 1979·European Journal of Pharmacology·T C SpauldingH Lal
Sep 24, 1982·European Journal of Pharmacology·D S HeronD Samuel
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·D H Overstreet
Apr 23, 2003·European Journal of Pharmacology·Herbert E Covington, Klaus A Miczek
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·James E SmithThomas J Martin

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