Changes in Serial D-Dimer Levels Predict the Prognoses of Trousseau's Syndrome Patients

Frontiers in Neurology
Shinji ItoTatsuro Mutoh

Abstract

Background: The development of acute multiple embolic infarctions (AMEI) resulting from cancer is known as Trousseau's syndrome (TS). At present, however, there is no good marker for predicting the prognosis of TS patients. In the present study, we evaluated the use of serial D-dimer levels as a prognostic marker for TS. Methods: This retrospective cohort study included 1,409 consecutive acute ischemic stroke patients. We selected a group of patients with TS showing AMEI (n = 38; TS group) and a group of patients with atrial fibrillation (Af) and AMEI (n = 35; Af group) as controls. Serial D-dimer levels were measured between days 7 and 28 after stroke (sub-acute phase) in 21 patients of the TS group and 24 patients of the Af group. Results: D-dimer levels at onset (acute phase) were significantly higher in the TS group (8.45 ± 1.79 μg/mL, n = 38) compared with the Af group (1.14 ± 0.14 μg/mL, n = 35) (p < 0.0001). In patients for whom serial D-dimer measurements were made, D-dimer levels measured at the sub-acute phase decreased to 0.48 ± 0.12 μg/mL (n = 24) in the Af group, but remained elevated in the TS group during the sub-acute phase (11.20 ± 2.77 μg/mL, n = 21) (p < 0.0001). In all TS patients in whom serial D-dimer meas...Continue Reading

References

Mar 4, 2000·Stroke; a Journal of Cerebral Circulation·J K RohK H Chang
Jun 9, 2004·Neurology·D M CestariL M DeAngelis
Jul 1, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Fabio Silvio TacconeSerge A Blecic
Jul 12, 2008·Acta Neurologica Scandinavica·W GrisoldW Struhal
Feb 13, 2010·Stroke; a Journal of Cerebral Circulation·Seon Gyeong KimOh Young Bang
Sep 18, 2012·PloS One·Suk Jae KimOh Young Bang
Sep 22, 2012·Stroke; a Journal of Cerebral Circulation·Christopher J SchwarzbachMarc Fatar
Dec 4, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yi-Jen GuoYi-Chu Liao
May 23, 2014·Neurology·Babak B NaviLisa M DeAngelis
Jul 6, 2014·Stroke; a Journal of Cerebral Circulation·Babak B NaviLisa M DeAngelis
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanUNKNOWN American Society of Clinical Oncology
Dec 10, 2015·Cerebrovascular Diseases Extra·Christopher Jan SchwarzbachKristina Szabo
Jul 28, 2016·Stroke; a Journal of Cerebral Circulation·Tomohisa NezuYoshiki Yagita
Aug 20, 2016·Journal of the Neurological Sciences·Shinji ItoTatsuro Mutoh

❮ Previous
Next ❯

Citations

Sep 27, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yitong LingJintao Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsy

Software Mentioned

MedCalc
JMP12
TFS

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.