Changes in serum and intestinal diamine oxidase (DAO) activity after proximal enterectomy in rats. Correlation of DAO activity with mucosal mass parameters

Digestive Diseases and Sciences
J P ButsC Dive

Abstract

To determine whether serum and mucosal DAO activity reflects quantitative changes in the small bowel mucosal mass, we have chosen an experimental model of mucosal hyperplasia which is known to occur in the rat after enterectomy. A 50% proximal enterectomy or a single transection was performed in 20 growing rats weighing 145-160 g. Ten days following surgery, we determined mucosal mass parameters (weight, protein, and DNA content), sucrase activity, and DAO activity in the duodenum (segment A), proximal ileum (segment B), and distal ileum (segment C) of the remaining small intestine. Mucosal hyperplasia was demonstrated by the finding that in each segment, mucosal weight, protein, and DNA content per centimeter of gut length were significantly (P less than 0.01) higher (+38 to + 78%) in the resected group than in transected controls. In segments B and C of resected rats, the changes in DAO activity expressed per gram of mucosa paralleled the changes in mucosal mass, the activity being increased by +69% and +49% (P less than 0.05) compared to the values recorded in transected controls. Expressed per centimeter of gut length, total DAO activity was also enhanced by +141% in segment B (P less than 0.05 vs controls) and by +87% in s...Continue Reading

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Citations

Sep 14, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·C H SmithG M Murphy
Jul 14, 2006·Digestive Diseases and Sciences·Jean-Paul Buts, Nadine De Keyser
Feb 14, 2009·Journal of Gastroenterology·Kenichi IshiiHideki Fujii
Feb 4, 2014·The International Journal of Eating Disorders·Yoshiyuki TakimotoAkira Akabayashi
Oct 1, 1992·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·J S ThompsonE M Quigley
Jan 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jun-Nan HuWei Li

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