Changes in serum and urine SAA concentrations and qualitative and quantitative proteinuria in Abyssinian cats with familial amyloidosis: a five-year longitudinal study (2009-2014)

Journal of Veterinary Internal Medicine
S PaltrinieriM Longeri

Abstract

Diagnosis of familial amyloidosis (FA) in Abyssinian cats usually is made on postmortem examination. Sequential analysis of serum SAA (sSAA), urinary SAA (uSAA), urinary protein:creatinine (UPC) ratio, or sodium-dodecylsulfate agarose gel electrophoresis (SDS-AGE) may facilitate early identification of cats with FA. Twenty-three Abyssinian cats belonging to cattery A or B (low and high prevalence of FA, respectively). Prospective longitudinal study using 109 blood and 100 urine samples collected over 4-year period every 4 months, if possible, or more frequently in case of illness. Cats that died during study were necropsied. Health status of live cats was checked 5 years after enrollment. Serum amyloid A (sSAA) and urinary SAA (uSAA) were measured using ELISA kit. The UPC ratio and SDS-AGE also was performed. Familial amyloidosis was not identified in cattery A, whereas 7/14 cats from cattery B had FA. Serum amyloid A concentrations were not significantly different between cats in catteries A and B or between cats with or without FA, despite frequent peaks in cats from cattery B. Conversely, uSAA was significantly higher in cattery B, especially in the terminal phases of FA. Proteinuria occasionally was found in cats from both ...Continue Reading

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Citations

May 19, 2017·Veterinary Clinical Pathology·Sakurako Neo-SuzukiKinji Shirota
Feb 7, 2019·Journal of Feline Medicine and Surgery·Marco GiraldiPaola Scarpa
Aug 19, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Gabriele RossiSaverio Paltrinieri
Apr 18, 2021·Scientific Reports·Francesca GenovaMaria Longeri

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