PMID: 108916May 1, 1979

Changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins during early infancy. Studies in healthy fullterm, small-for-gestational age and preterm infants aged 7 to 240 days

Acta paediatrica Scandinavica
B B Jacobsen, L Hummer

Abstract

Serum concentrations of thyrotropin (TSH), thyroxine (T4), triiodothyronine (T3), thyroxine-binding globulin (TBG), prealbumin (TBPA) and albumin (Alb) were determined in 492 blood samples from 127 fullterm (FT), 91 small-for-gestational age (SGA) and 88 preterm (PT) healthy infants aged 7 to 240 days. Serum T4 decreased about 20% during the first month of life. In infants aged 7--49 days, serum T4 concentrations were significantly lower in SGA than in FT infants, and even lower values were found in PT infants. Serum T3 increased 50--70% reaching maximal values by 50--79 days of life. Serum T3 levels were higher in FT than in SGA infants throughout the observation period. In PT infants serum T3 increased from low values to levels which exceeded those of SGA and FT infants by 120--240 days of life. Serum TSH level did not change with age and was less than or equal to 5 mU/l in all infants. Serum TBG values were high compared to normal adult values and did not change significantly with age. Comparable serum TBG values were found in FT, SGA and PT infants. Serum TBPA increased with age. Serum TBPA increased gradually in FT infants. In SGA infants serum TBPA increased from low values to levels which by 120--240 days of life exceede...Continue Reading

References

Mar 1, 1977·Clinical Endocrinology·J Bernal, S Refetoff
Mar 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R D HeschP Stubbe
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·D A FisherM E Parslow
Jul 1, 1975·Acta paediatrica Scandinavica·H VerderE Scheibel
Mar 1, 1974·Archives of Disease in Childhood·T G BrienE A Griffin
Nov 1, 1974·The Journal of Clinical Endocrinology and Metabolism·G C Hays, J E Mullard
Aug 1, 1974·The Journal of Clinical Endocrinology and Metabolism·J AbuidP R Larsen
Jan 1, 1973·Acta Endocrinologica. Supplementum·J HomokiW M Teller
Aug 1, 1972·Journal of Clinical Pathology·J Ryness
Nov 1, 1972·The Journal of Pediatrics·M T O'Halloran, H L Webster
Apr 1, 1974·Scandinavian Journal of Clinical and Laboratory Investigation·M KoivistoM Reinilä
Apr 1, 1968·Archives of Disease in Childhood·M A ChaddO P Gray

Citations

Mar 19, 1981·The New England Journal of Medicine·D A Fisher, A H Klein
Oct 1, 1981·Archives of Disease in Childhood·B B Jacobsen
Feb 1, 1985·Archives of Disease in Childhood·R C FranklinC M O'Grady
Oct 1, 1988·Archives of Disease in Childhood·A LucasR Morley
Nov 15, 2012·Journal of Clinical Research in Pediatric Endocrinology·Bagnoli FrancoGrosso Salvatore
Nov 15, 2008·Seminars in Perinatology·Jerald C NelsonR Bruce Wilcox
May 1, 1983·The Journal of Pediatrics·S R MoskowitzJ B Watkins
May 1, 1985·Postgraduate Medical Journal·M R WilkinsM J Kendall
Apr 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miles J De BlasioJulie A Owens
Mar 1, 2010·Expert Review of Endocrinology & Metabolism·Jane E HardingFrank H Bloomfield
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·J SaslowM Fernandes D'Souza
Feb 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·L HummerB B Jacobsen
Jan 26, 2021·Frontiers in Neuroendocrinology·Maurice PagninMary Tolcos

Related Concepts

Neonatal Prematurity
Infant, Small for Gestational Age
Plasma Albumin
Thyroid Hormones
Thyrotropin
Novothyral
Thyroxine-Binding Proteins
Cytomel

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Incretins

Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.