PMID: 108916May 1, 1979

Changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins during early infancy. Studies in healthy fullterm, small-for-gestational age and preterm infants aged 7 to 240 days

Acta paediatrica Scandinavica
B B Jacobsen, L Hummer


Serum concentrations of thyrotropin (TSH), thyroxine (T4), triiodothyronine (T3), thyroxine-binding globulin (TBG), prealbumin (TBPA) and albumin (Alb) were determined in 492 blood samples from 127 fullterm (FT), 91 small-for-gestational age (SGA) and 88 preterm (PT) healthy infants aged 7 to 240 days. Serum T4 decreased about 20% during the first month of life. In infants aged 7--49 days, serum T4 concentrations were significantly lower in SGA than in FT infants, and even lower values were found in PT infants. Serum T3 increased 50--70% reaching maximal values by 50--79 days of life. Serum T3 levels were higher in FT than in SGA infants throughout the observation period. In PT infants serum T3 increased from low values to levels which exceeded those of SGA and FT infants by 120--240 days of life. Serum TSH level did not change with age and was less than or equal to 5 mU/l in all infants. Serum TBG values were high compared to normal adult values and did not change significantly with age. Comparable serum TBG values were found in FT, SGA and PT infants. Serum TBPA increased with age. Serum TBPA increased gradually in FT infants. In SGA infants serum TBPA increased from low values to levels which by 120--240 days of life exceede...Continue Reading


Mar 1, 1977·Clinical Endocrinology·J Bernal, S Refetoff
Mar 1, 1977·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R D HeschP Stubbe
Aug 1, 1977·The Journal of Clinical Endocrinology and Metabolism·D A FisherM E Parslow
Jul 1, 1975·Acta paediatrica Scandinavica·H VerderE Scheibel
Mar 1, 1974·Archives of Disease in Childhood·T G BrienE A Griffin
Nov 1, 1974·The Journal of Clinical Endocrinology and Metabolism·G C Hays, J E Mullard
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Apr 1, 1968·Archives of Disease in Childhood·M A ChaddO P Gray


Mar 19, 1981·The New England Journal of Medicine·D A Fisher, A H Klein
Oct 1, 1981·Archives of Disease in Childhood·B B Jacobsen
Feb 1, 1985·Archives of Disease in Childhood·R C FranklinC M O'Grady
Oct 1, 1988·Archives of Disease in Childhood·A LucasR Morley
Nov 15, 2012·Journal of Clinical Research in Pediatric Endocrinology·Bagnoli FrancoGrosso Salvatore
Nov 15, 2008·Seminars in Perinatology·Jerald C NelsonR Bruce Wilcox
May 1, 1983·The Journal of Pediatrics·S R MoskowitzJ B Watkins
May 1, 1985·Postgraduate Medical Journal·M R WilkinsM J Kendall
Apr 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miles J De BlasioJulie A Owens
Mar 1, 2010·Expert Review of Endocrinology & Metabolism·Jane E HardingFrank H Bloomfield
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·J SaslowM Fernandes D'Souza
Feb 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·L HummerB B Jacobsen
Jan 26, 2021·Frontiers in Neuroendocrinology·Maurice PagninMary Tolcos

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Neonatal Prematurity
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