Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata

Mycotoxin Research
Fadeyemi J AkinrinmadeAdetayo Amid

Abstract

Aflatoxins are known to produce chronic carcinogenic, mutagenic, and teratogenic effects, as well as acute inflammatory effects, especially in the gastrointestinal tract. The potentials of the flavonoid-rich extract from Chromolena odorata (FCO) and melatonin (a standard anti-oxidant and anti-inflammatory agent) against aflatoxin B1 (AFB1)-induced alterations in pro-inflammatory cytokine levels and morphology of liver and small intestines were evaluated in this study. We utilized Wistar albino rats (200-230 g) randomly divided into five groups made up of group A, control rats; group B, rats given AFB1 (2.5 mg/kg, intraperitoneal) twice on days 5 and 7; rats in groups C, D, and E were treated with melatonin (10 mg/kg, intraperitoneal) or oral doses of FCO1 (50 mg/kg) and FCO2 (100 mg/kg) for 7 days, respectively, along with AFB1 injection on days 5 and 7. Serum levels of interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were determined using commercial ELISA kits and histopathological evaluation of the liver, duodenum, and ileum were also carried out. We observed significant elevation (p < 0.05) in serum IL-1β correlating with hemorrhages and leucocytic and lymphocytic infiltration in the liver and intestines as...Continue Reading

References

Jan 1, 1987·Veterinary Pathology·D C Baker, R A Green
Feb 1, 1996·Steroids·M TijmesL Valladares
May 30, 1998·Toxicon : Official Journal of the International Society on Toxinology·S KumagaiA Ogura
Mar 30, 1999·Research in Microbiology·F RossanoM R Catania
Jul 20, 1999·International Journal of Immunopharmacology·E Y MoonS Pyo
Jun 1, 2000·Journal of Pineal Research·A ContiJ M Maestroni
Aug 11, 2000·The American Journal of Medicine·B M Babior
Sep 9, 2000·Toxicon : Official Journal of the International Society on Toxinology·E ItoK Harada
Apr 24, 2001·Journal of Pineal Research·C C WuM H Yen
Oct 25, 2002·Digestive Diseases and Sciences·George A Bubenik
Mar 23, 2004·Toxicon : Official Journal of the International Society on Toxinology·Nicolette BothaMichelle M Gehringer
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihide Kanaoka, Joshua A Boyce
Dec 14, 2004·Toxicology·Maria Francesca CometaMaura Palmery
Feb 8, 2005·Toxicology and Applied Pharmacology·William KernsUNKNOWN Expert Working Group on Drug-Induced Vascular Injury
May 3, 2005·International Journal of Food Microbiology·G S JosephK K Sakariah
Nov 11, 2005·Inflammopharmacology·Victor B OwoyeleAyodele O Soladoye
Feb 7, 2006·Cancer Letters·Leanne L Bedard, Thomas E Massey
Dec 19, 2006·International Journal of Food Microbiology·Rajesh KumarY B Tripathi
Dec 29, 2006·Cancer Biomarkers : Section a of Disease Markers·Sandrine LacourRuth Roberts
Jan 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Thérèse SergentYves-Jacques Schneider
May 27, 2008·Toxicology and Applied Pharmacology·Guylaine M MeissonnierIsabelle P Oswald
May 8, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jacqueline M Tarrant
Dec 25, 2010·World Journal of Gastroenterology : WJG·Alexander M Mathes
Oct 22, 2011·Asian Pacific Journal of Tropical Medicine·Tran Thi Hong HanhNguyen Tien Dat
May 30, 2012·Toxicology·Kerstin Gross-Steinmeyer, David L Eaton
Mar 20, 2013·Journal of Applied Toxicology : JAT·Guoqing QianJia-Sheng Wang
Oct 18, 2014·Journal of Complementary & Integrative Medicine·Joseph Fadeyemi AkinrinmadeAdetokunbo Ademola Oyagbemi

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Citations

Mar 24, 2017·International Journal of Molecular Sciences·Jiao-Jiao ZhangHua-Bin Li
Jan 18, 2017·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Jaroslav SlameckaPeter Massanyi
Jun 22, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Hervé RobertIsabelle P Oswald
Feb 23, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Adetayo Sadudeen AmidFadeyemi Joseph Akinrinmade
Mar 15, 2018·Frontiers in Cellular and Infection Microbiology·Winnie-Pui-Pui Liew, Sabran Mohd-Redzwan
Jun 21, 2017·BioMed Research International·Cezary ChojnackiJan Chojnacki
Sep 22, 2020·Mycotoxin Research·Akinleye Stephen AkinrindeFadeyemi Joseph Akinrinmade
Oct 2, 2020·Toxins·Yanan GaoNan Zheng
Jan 14, 2021·Toxins·Yun GuanKamil Kuca
Oct 17, 2020·Critical Reviews in Food Science and Nutrition·Moamen M ElmassryMohamed A Farag

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