PMID: 6104934Jan 1, 1980Paper

Changes in serum enzyme levels following ketamine infusions

Anaesthesia
J W DundeeD B Wilson

Abstract

The levels of four serum enzymes, known to be elevated in toxic hepatitis, were measured preoperatively and on the 3-4th and 13-15th postoperative days in patients anaesthetised with ketamine infusions (54) or with a standard technique (64). Significant elevations in enzyme levels were considered to have occurred when the postoperative levels were outside the accepted normal range and had increased by more than 3 X SD from controls. About half the patients in each group had minor gynaecological operations and 2/20 in the ketamine series had postoperative elevation of enzyme levels, with no changes in the non-ketamine group. Following intermediate operations 14/34 anaesthetised with ketamine showed abnormal enzyme levels compared with 7/34 who had standard operations. None of the latter had more than one abnormal test as compared with six in the ketamine series. The causes and significance of these findings are not known.

References

Feb 1, 1976·British Journal of Anaesthesia·R S ClarkeT Lavery

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Citations

Jul 1, 1986·Archives of Toxicology·S G AdhvaryuB J Dave
Jan 1, 1984·Canadian Anaesthetists' Society Journal·T M Bird, L Strunin
Jun 28, 1986·British Medical Journal·C E Blogg
Jul 21, 2011·Journal of Anaesthesiology, Clinical Pharmacology·Deb Sanjay NagPratap Rudra Mahanty
Feb 27, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Petr Cvrcek
Nov 26, 2013·Natural Product Reports·James M BalkovecSheo B Singh
Jun 9, 2016·Journal of Anaesthesiology, Clinical Pharmacology·Andrew W GorlinHarish Ramakrishna
May 11, 2013·The Australian and New Zealand Journal of Psychiatry·Natalie KatalinicColleen K Loo
Jul 1, 2014·Frontline Gastroenterology·Roisin Bevan, Denis Burke
Feb 1, 1981·Anaesthesia·W P BlunnieP D McIlroy
Jun 1, 1981·Anaesthesia·H G McNeillL P Briggs
Mar 1, 1982·Anaesthesia·P KawarG S Nesbitt
Feb 26, 2013·British Journal of Clinical Pharmacology·Marieke NiestersAlbert Dahan
Jul 10, 2020·A&A Practice·Xiaoying ZhuRobert B Goldstein
Oct 27, 2021·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Samantha CotterMallika Mundkur

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