PMID: 9534918Apr 16, 1998Paper

Changes in serum haptoglobin level after allergen challenge test in asthmatic children

Allergy
C K KimY Y Koh

Abstract

Bronchial asthma is characterized by airway inflammation, which underlies the phenomenon of bronchial hyperresponsiveness. Previous studies have shown that this correlates with the serum concentration of haptoglobin. The occurrence of the late asthmatic response (LAR) after an allergen challenge test is associated with airway inflammation. The objectives of this study were to examine serum levels of haptoglobin during the 24 h after allergen challenge and to compare changes between the subjects with and without LAR. We studied two groups of children with perennial asthma who developed the early asthmatic response (EAR) only (group I: n = 14), and EAR but also LAR (group II: n = 14) after an allergen (Dermatophagoides pteronyssinus) challenge test. Serum concentrations of haptoglobin were measured at baseline, at EAR, and at 2 h (recovery), 8 h (LAR), and 24 h after the challenge. Baseline levels were similar in the two groups (group I: 128 +/- 57 mg/dl; group II: 129 +/- 50 mg/dl). In group I, there was no significant change in the level at any time point; in contrast, the subjects in group II showed a relative fall (92 +/- 40 mg/dl) at 8 h, and an increase (161 +/- 79 mg/dl) at 24 h after the challenge. Our results indicate th...Continue Reading

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Citations

Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Nicole M VerrillsPeter G Gibson
Sep 6, 2000·American Journal of Respiratory Cell and Molecular Biology·F YangJ J Coalson
Jan 1, 2008·Proteomics. Clinical Applications·Tatsuji NishiokaEmiko Noguchi
Sep 27, 2003·Analytical Biochemistry·Tracey WeilerJohn A Wilkins
Oct 5, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R CastanoA Cartier

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