PMID: 22587919May 17, 2012Paper

Changes in serum high mobility group box-1 protein and high-sensitivity C-reactive protein in patients with acute cerebral infarction and their clinical significance

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Ping ZhouYan Yu

Abstract

To study the potential role of high mobility group box-1 protein (HMGB1) and high-sensitivity C-reactive protein (hs-CRP) in acute cerebral infarction (ACI). Forty patients with ACI were enrolled within 72 hours after onset of symptom in this study. Venous blood samples were collected within 24 hours of admission, 7th day and 12th day after admission. Serum HMGB1 and hs-CRP levels were measured with enzyme linked immunosorbent assay (ELISA) method. Serum HMGB1 levels (μg/L) at all time points (24 hours: 7.598±0.280, 7th day: 10.491±0.512, 12th day: 5.315±0.224) were significantly higher than those of healthy controls (n=20, 2.994±0.243) and risk factor group in which patients suffered from one risk factor in hypertension, diabetes mellitus, and hyperlipemia at least (n=20, 3.272±0.285), with significant difference (all P<0.01). Serum hs-CRP levels (mg/L, 24 hours: 5.815±0.408, 7th day: 5.063±0.510, 12th day: 2.863±0.297) of the patients were also significantly higher than those of healthy controls (0.642±0.047), with significant difference (all P<0.01), and serum hs-CRP levels on 12th day were similar to that in risk factor group (2.514±0.312), with no significant difference (P>0.05). Serum HMGB1 levels in risk factor group wer...Continue Reading

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