Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease

Menopause : the Journal of the North American Menopause Society
Helena GyllingTatu A Miettinen

Abstract

Especially in women, serum cholesterol lowering with cholesterol malabsorption using plant sterol ester margarine has revealed controversial results. Accordingly, in this retrospective study, we evaluated whether plant stanol (3 g/d) ester margarine consumption for 6 and 12 weeks lowers serum cholesterol levels in mildly hypercholesterolemic women without (n = 38) and with (n = 22) coronary heart disease. The study population was selected from two of our earlier studies correspondingly matched for age, body mass index, and serum cholesterol and triglyceride levels. In addition, the long-term effect (12 months) of plant stanol ester with a dose reduction after 6 months (from 3-2 g stanol/d) was studied in the noncoronary group. At baseline, the coronary and noncoronary groups had similar serum lathosterol (synthesis marker) and campesterol and sitosterol (absorption markers) ratios to cholesterol, but high-density lipoprotein cholesterol was lower and serum squalene and desmosterol ratios to cholesterol were significantly higher in the coronary versus noncoronary groups. Short-term plant stanol ester consumption reduced serum cholesterol by 8.7% (P < 0.001) in the coronary group from the control margarine period, and in the nonc...Continue Reading

References

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Dec 19, 2002·Metabolism: Clinical and Experimental·Thomas SudhopKlaus von Bergmann
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May 4, 2004·Annals of Medicine·Tatu A Miettinen, Helena Gylling
Aug 28, 2004·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·F H O'NeillG R Thompson

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Citations

Oct 12, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·V S NunesE C R Quintão
Feb 2, 2008·Journal of the American Dietetic Association·Linda Van HornGeeta Sikand
Jun 19, 2016·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·José Félix Meco LópezRosa Solà Alberich
Oct 14, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Victoria Shanta RetelnyJulie L Roth
Jun 4, 2008·Menopause International·Iwona Rudkowska
Jan 12, 2022·Journal of Agricultural and Food Chemistry·Virginia Blanco-MoralesGuadalupe Garcia-Llatas

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