PMID: 8971882Dec 1, 1996Paper

Changes in serum lipoprotein(a) levels in children with corticosensitive nephrotic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
R GarnotelP Gillery

Abstract

Variations in lipoprotein(a) [Lp(a)] levels were evaluated during the course of the nephrotic syndrome in 20 children (17 males, 3 females, aged 2-16 years), to evaluate the use of this parameter in the prognosis and monitoring of the disease. One patient was in relapse, 12 in remission, and 7 alternated between remission and relapse. Results were compared with those obtained in a control population of 100 age-matched children. Lp(a) was measured by a previously described immunonephelometric technique. Serum Lp(a) levels were increased in children with relapsing nephrotic syndrome compared with controls (median value of 419 mg/l vs. 86 mg/l). The median Lp(a) level in patients with nephrotic syndrome in remission was different from controls (270 mg/l under steroid therapy and 163 mg/l without steroid therapy), but remained within the reference range. Of the patients in relapse, 66% had Lp(a) levels above the generally accepted limit for cardiovascular risk of 300 mg/l, compared with 16% of controls, 44% of patients with nephrotic syndrome in remission under steroid therapy, and 18% of patients with nephrotic syndrome in remission without steroid therapy. In 2 patients, Lp(a) was measured repeatedly and was significantly higher ...Continue Reading

Citations

Aug 7, 1998·European Journal of Clinical Investigation·I Karádi
May 1, 2002·Current Opinion in Pediatrics·Jeffrey M SalandEdward A Fisher
Jul 24, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·R GarnotelP Gillery
Mar 25, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mona Khurana, Douglas M Silverstein
May 23, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chunni ZhangJunjun Wang
Oct 28, 2004·The Annals of Pharmacotherapy·William A PrescottDaniel S Streetman

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