Abstract
Low-risk patients with differentiated thyroid cancer can be treated with thyroid lobectomy. Serial measurements of serum thyroglobulin (Tg) are recommended for surveillance, but the cutoff values indicating recurrence are not known. This study documented the natural course of serum Tg levels during follow-up after lobectomy for low-risk papillary thyroid carcinoma (PTC) and evaluated whether changes in serum Tg levels predict disease recurrence. This historical cohort study included 208 patients with low-risk PTC who underwent lobectomy but did not require hormone replacement. Postoperative serum Tg levels and Tg/thyrotropin (TSH) ratios and neck ultrasound were evaluated during a follow-up period with a median of 6.9 years. The serum Tg levels increased gradually, and the proportion of patients with levels >10 ng/dL increased annually by 13.9%, 18.8%, 22.1%, 21.9%, 28.4%, and 28.9% during the six-year follow-up period (β = 0.574, p = 0.027). The relative serum Tg levels increased by 10% annually (β = 0.105, p < 0.001), and the levels of Tg and Tg/TSH ratios in 19 patients with recurrent disease did not differ significantly (β = 0.150, p = 0.090). Patients without recurrent disease were more likely to have serum Tg levels incre...Continue Reading
References
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·H J Baskin
Nov 1, 1996·Annals of Surgical Oncology·A R ShahaT R Loree
Feb 1, 1997·Annals of Internal Medicine·G H Tan, H Gharib
Apr 16, 1998·European Journal of Endocrinology·M Schlumberger, E Baudin
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Anne BachelotMartin Schlumberger
Jan 22, 2003·European Journal of Endocrinology·Massimo TorlontanoVincenzo Trischitta
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Massimo TorlontanoSebastiano Filetti
Sep 24, 2009·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossSteven I Sherman
Oct 29, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid CancerR Michael Tuttle
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Cosimo DuranteUNKNOWN Papillary Thyroid Cancer Study Group
Apr 28, 2011·Clinical Endocrinology·F VaismanR Michael Tuttle
Jul 29, 2011·The Journal of Clinical Endocrinology and Metabolism·Cosimo Durante, Sebastiano Filetti
Feb 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Claire SchvartzMichel Toubeau
Jun 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Cosimo DuranteUNKNOWN PTC Study Group
Jun 6, 2013·Journal of Cancer Epidemiology·Gabriella PellegritiRiccardo Vigneri
Dec 11, 2013·Thyroid : Official Journal of the American Thyroid Association·Yun Mi ChoiWon Bae Kim
Jan 24, 2014·Journal of Thyroid Research·Fernanda VaismanR Michael Tuttle
Jan 22, 2015·Thyroid : Official Journal of the American Thyroid Association·Min Ji JeonWon Bae Kim
Oct 16, 2015·Thyroid : Official Journal of the American Thyroid Association·Bryan R HaugenLeonard Wartofsky
Mar 30, 2016·The Journal of Clinical Endocrinology and Metabolism·Denise P MomessoR Michael Tuttle
Oct 6, 2016·Endocrinology and Metabolism·Ka Hee Yi
Oct 21, 2016·Oncotarget·Dandan YiJianfeng Sang
Nov 22, 2016·Thyroid : Official Journal of the American Thyroid Association·Suyeon ParkWon Bae Kim
Jan 17, 2017·European Journal of Endocrinology·Hyemi KwonWon Bae Kim
Dec 5, 2017·Endocrinology and Metabolism·Min Ji JeonUNKNOWN Korean Thyroid Cancer Study Group
Citations
Oct 11, 2019·Current Opinion in Oncology·Luca Giovanella
Oct 31, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Bo Young KimYoung- Ik Son
Feb 7, 2020·The British Journal of Surgery·D AhnJ H Sohn
Mar 29, 2020·The Journal of Clinical Endocrinology and Metabolism·Amit RitterEyal Robenshtok
May 14, 2020·Journal of Endocrinological Investigation·A CampennìL Giovanella
Jul 28, 2020·Journal of Clinical Medicine·Andreea BojogaRomana Netea-Maier
Jul 20, 2019·Endocrine Reviews·Donald S A McLeodDavid S Cooper
Apr 25, 2020·World Journal of Surgery·Jianlu SongZhili Yang
Sep 19, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Minxia HuHanxue Zhao
Nov 21, 2020·The Journal of International Medical Research·Fuxin LiThomas J Fahey
Nov 28, 2020·ANZ Journal of Surgery·Saam S TouraniJustin Gundara
Jan 9, 2021·Annals of Surgical Oncology·Carla ColomboLaura Fugazzola
Jan 14, 2021·ANZ Journal of Surgery·Alexander J PapachristosStan B Sidhu
Jul 7, 2020·Minerva endocrinologica·Carla GambaleAntonio Matrone
Feb 11, 2021·Annals of Surgical Oncology·Carla ColomboLaura Fugazzola
Nov 12, 2020·Cancers·Dana M HartlSophie Leboulleux
Nov 7, 2020·Medicina·Noor AddasiWhitney Goldner
May 21, 2021·International Journal of Cancer. Journal International Du Cancer·Fadi NabhanMatthew D Ringel
May 31, 2021·Asian Journal of Surgery·David LeongSimon Ryan
Jul 14, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Lucy Qian LiIain James Nixon
Jul 25, 2021·Cancers·Ayanthi A WijewardeneMartyn Bullock
Aug 4, 2021·Thyroid : Official Journal of the American Thyroid Association·Siyuan XuJie Liu
Feb 26, 2019·European Thyroid Journal·Pedro Weslley RosarioMaria Regina Calsolari