PMID: 1197542Nov 1, 1975Paper

Changes in serum tryptophan and albumin binding of tryptophan in chlorpromazine-treated chronic schizophrenics on withdrawal and restoration of drug therapy

Psychological Medicine
D A BenderN Hammond

Abstract

Withdrawal of drug from a group of chlorpromazine-treated chronic male schizophrenics led to a significant rise in the initially low serum tryptophan concentration, and a rise in the fraction freely diffusible. These changes, which would be expected to lead to an increase in tryptophan influx into the brain, and hence to an increase in cerebral serotonin synthesis, could be related to the clinical effects of drug withdrawal.

References

May 1, 1974·Journal of Neurochemistry·D A Bender, A N Bamji
Nov 1, 1974·Clinical Science and Molecular Medicine·G CurzonM H Lader
Apr 19, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·D Mikac-DevićK Bosković
Jan 1, 1974·Journal of Neural Transmission·W BirkmayerP Riederer
Sep 1, 1967·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A BenassiA De Antoni

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·D A Bender

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