Changes in short-chain acyl-coA dehydrogenase during rat cardiac development and stress

Journal of Cellular and Molecular Medicine
Jinxian HuangSi-Gui Zhou

Abstract

This study was designed to investigate the expression of short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid β-oxidation, during rat heart development and the difference of SCAD between pathological and physiological cardiac hypertrophy. The expression of SCAD was lowest in the foetal and neonatal heart, which had time-dependent increase during normal heart development. In contrast, a significant decrease in SCAD expression was observed in different ages of spontaneously hypertensive rats (SHR). On the other hand, swim-trained rats developed physiological cardiac hypertrophy, whereas SHR developed pathological cardiac hypertrophy. The two kinds of cardiac hypertrophy exhibited divergent SCAD changes in myocardial fatty acids utilization. In addition, the expression of SCAD was significantly decreased in pathological cardiomyocyte hypertrophy, however, increased in physiological cardiomyocyte hypertrophy. SCAD siRNA treatment triggered the pathological cardiomyocyte hypertrophy, which showed that the down-regulation of SCAD expression may play an important role in pathological cardiac hypertrophy. The changes in peroxisome proliferator-activated receptor α (PPARα) was accordant with that of SCAD. Moreover, the ...Continue Reading

References

Jun 23, 2000·The Journal of Clinical Investigation·P M BargerD P Kelly
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Motoyuki IemitsuIwao Yamaguchi
Jan 12, 2008·Cardiovascular Research·Pascal J H SmeetsMarc van Bilsen
May 20, 2009·Journal of Molecular and Cellular Cardiology·S RimbaudR Ventura-Clapier
Mar 1, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Biao SunJi Zheng Ma
Jun 26, 2010·Journal of Cardiovascular Translational Research·Pankaj K BhavsarPaul J R Barton
Jan 25, 2011·Cardiovascular Research·E Dale Abel, Torsten Doenst
Jan 26, 2011·Molecular and Cellular Biochemistry·Sreeja PurushothamanA C Fernandez
May 18, 2012·Cardiovascular Research·Michael S DoddDamian J Tyler
Sep 18, 2012·Journal of Molecular and Cellular Cardiology·Mariana G RoscaCharles L Hoppel
Nov 6, 2012·Heart Failure Reviews·N SiddiqiM Frenneaux
Nov 12, 2013·The Biochemical Journal·Marthe H R LudtmannAlbena T Dinkova-Kostova

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Citations

Mar 19, 2016·Journal of Cellular and Molecular Medicine·Zhenhua ZengSigui Zhou
Feb 20, 2021·Circulation·Andrew N CarleyE Douglas Lewandowski
Mar 7, 2021·Free Radical Biology & Medicine·Chrishan J A RamachandraDerek J Hausenloy

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