Changes in Skeletal Microstructure Through Four Continuous Years of rhPTH(1-84) Therapy in Hypoparathyroidism.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Natalie E CusanoJohn P Bilezikian

Abstract

Bone remodeling is reduced in hypoparathyroidism, resulting in increased areal bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) and abnormal skeletal indices by transiliac bone biopsy. We have now studied skeletal microstructure by high-resolution peripheral quantitative computed tomography (HR-pQCT) through 4 years of treatment with recombinant human PTH(1-84) (rhPTH[1-84]) in 33 patients with hypoparathyroidism (19 with postsurgical disease, 14 idiopathic). We calculated Z-scores for our cohort compared with previously published normative values. We report results at baseline and 1, 2, and 4 years of continuous therapy with rhPTH(1-84). The majority of patients (62%) took rhPTH(1-84) 100 μg every other day for the majority of the 4 years. At 48 months, areal bone density increased at the lumbar spine (+4.9% ± 0.9%) and femoral neck (+2.4% ± 0.9%), with declines at the total hip (-2.3% ± 0.8%) and ultradistal radius (-2.1% ± 0.7%) (p < .05 for all). By HR-pQCT, at the radius site, very similar to the ultradistal DXA site, total volumetric BMD declined from baseline but remained above normative values at 48 months (Z-score + 0.56). Cortical volumetric BMD was lower than normative controls at baseline at the ...Continue Reading

References

Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·M ParisienD W Dempster
Mar 22, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C H Turner
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Fredriech K W ChanChi-Chung Shek
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Stephanie BoutroyPierre D Delmas
Dec 16, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaL Joseph Melton
Apr 6, 2006·Clinical Endocrinology·Bashir Ahmad LawayAshu Seith
Jul 25, 2008·The New England Journal of Medicine·Dolores Shoback
Aug 8, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian
Jan 20, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N DalzellJ Reeve
Apr 3, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G BoivinP D Delmas
Apr 30, 2009·The Journal of Clinical Endocrinology and Metabolism·Edda VignaliClaudio Marcocci
May 21, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A CohenE Shane
Jan 23, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M R RubinJ P Bilezikian
Jul 2, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heather M MacdonaldSteven K Boyd
Jul 8, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian
Jul 21, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tanja SikjaerUNKNOWN Hypoparathyroid Study Group
Apr 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rachel I GafniMichael T Collins
Nov 20, 2012·The Journal of Clinical Endocrinology and Metabolism·Natalie E CusanoJohn P Bilezikian
Dec 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emily M SteinJohn P Bilezikian
Mar 23, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Åshild BjørneremEgo Seeman
May 9, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Line UnderbjergLars Rejnmark
Mar 11, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Line UnderbjergLars Rejnmark
Mar 18, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel SundhMattias Lorentzon
Aug 4, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalie E CusanoJohn P Bilezikian
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Dolores M ShobackRoger Bouillon
Mar 12, 2016·The Journal of Clinical Endocrinology and Metabolism·J N TsaiB Z Leder
May 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Mishaela R RubinJohn P Bilezikian
May 19, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lauren A BurtSteven K Boyd
Dec 17, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J C AlvarengaR M R Pereira
Mar 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduRoland D Chapurlat
Jul 5, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mishaela R RubinJohn P Bilezikian

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Citations

Nov 18, 2020·Reviews in Endocrine & Metabolic Disorders·Barbara C Silva, John P Bilezikian
Mar 18, 2021·Nature Reviews. Endocrinology·Andrew ArnoldRajesh V Thakker
May 21, 2021·Minerva Endocrinology·Yu-Kwang D TayJohn P Bilezikian

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