PMID: 7009Apr 1, 1976Paper

Changes in skeletal muscle cell pH during graded changes in PCO2

Respiration Physiology
N C Gonzalez, E B Brown

Abstract

Blood perfusing isolated dog gracilis muscles was equilibrated with CO2 tensions ranging from 30 to 120 mm Hg, resulting in venous P CO2 from 35 to 135 mm Hg. Extracellular pH values ranged from 6.96 to 7.41, and muscle cell pH, calculated from DMO distribution, ranged from 6.64 to 6.94. When intracellular pH was plotted as a function of the corresponding extracellular pH, a linear relationship (r = 0.92) was observed throughout the entire pH range. The slope deltapHi/deltapHe was 0.64, without evidence of a difference in slope at different pH values. These results do not support the previous observations in rat diaphragms that cell pH is not affected by PCO2 changes over a certain extracellular pH range. pHe was 0.64, without evidence of a difference in slope at different pH values. Theses results do not support the previous observations in rat diaphragms that cell pH is not affected by PCO2 changes over a certain extracellular pH range.

References

Jun 29, 1966·Biochimica Et Biophysica Acta·H K Delcher, J C Shipp
Oct 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·B K Siesjö
Nov 1, 1973·Respiration Physiology·Y L LaiE B Brown
Sep 8, 1970·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·N C González, O A Gende
Nov 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E B BrownF A Moorhead
Aug 1, 1958·The Journal of Clinical Investigation·G NICHOLS

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Citations

Apr 5, 1984·The New England Journal of Medicine·G JuanC Roussos
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·G F RaffertyJ Moxham
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·M Montes de Oca, B R Celli
Dec 1, 1983·Acta Anaesthesiologica Scandinavica·K F Rothe
Jun 26, 2015·Medicine and Science in Sports and Exercise·Thomas RuppSamuel Verges
Sep 1, 1981·Journal of Muscle Research and Cell Motility·K A Edman, A R Mattiazzi
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·T McLellanW Lewis

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