Changes in somatostatin-like activity in discrete areas of the rat hypothalamus during different stages of proestrus and diestrus and their relation to serum gonadotropin, prolactin, and growth hormone levels

Endocrinology
U A KnuthH G Friesen

Abstract

To investigate physiological changes in the somatotropin release-inhibiting factor (SRIF) content of the hypothalamus during the estrous cycle, groups of 8-10 rats were decapitated every 2 h from 0800-1800 h on proestrus and diestrus. SRIF was assayed in the preoptic suprachiasmatic area, posterior hypothalamus, arcuate nucleus area, and median eminence. Gonadotropins, PRL, and GH were measured in trunk blood and correlated with concentrations of SRIF. A marked decrease in SRIF occurred between 0800-1400 h of proestrus in the preoptic suprachiasmatic area (1.00 +/- 0.28 vs. 0.09 +/- 0.03 micrograms/g wet wt, P less than 0.001) and the posterior hypothalamus (0.43 +/- 0.10 vs. 0.02 +/- 0.004 micrograms/g, P less than 0.001). A similar pattern of decrease in SRIF also occurred in the tissue containing the arcuate nucleus (2.09 +/- 0.37 vs. 0.98 +/- 0.13 micrograms/g, P less than 0.01). In the median eminence the lowest SRIF concentration was measured at 1600 h (31.4 +/- 3.4 vs. 22.0 +/- 1.32 micrograms/g, P less than 0.02). Diestrous values for SRIF did not change in the posterior hypothalamus and arcuate area; however, values increased slightly in the median eminence and decreased in the preoptic suprachiasmatic area between 140...Continue Reading

Citations

Apr 19, 2008·Experimental Brain Research·Harmke H Van VugtEline M Van der Beek
Feb 6, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Eliiyahu StoupelDaiva Virvichiute
Nov 22, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Eliyahu G Stoupel
May 18, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Eliyahu G Stoupel

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