Changes in spinal cord injury-induced gene expression in rat are strain-dependent

The Spine Journal : Official Journal of the North American Spine Society
Caroline SchmittDaniel K Resnick

Abstract

The functional recovery of animals subject to experimental spinal cord injury (SCI) is dependent on the injury model as well as the species and strain of animal used. Previous studies have shown differences in rates and degree of recovery between rats of different strains. We sought to explore the hypothesis that differences in gene expression are associated with differences in functional recovery. Laboratory study involving cohorts of three different strains of rat. We used the Impactor device to produce identical spinal cord contusion injuries in groups of Long Evans, Sprague-Dawley, and Lewis rats (10 each). The functional recovery of animals was assessed using the Basso, Beattie, and Bresnahan rating scale. Six weeks after injury, rats were killed and the spinal cords were harvested for deoxyribonucleic acid microarray analysis. Changes in gene expression compared with intraspecies controls (3 each) were assessed at the region of injury and at a rostral segment of the spinal cord. Selected genes were also studied with real-time polymerase chain reaction. We found that different strains tended to exhibit different patterns of functional recovery. There were differences between the strains in terms of gene expression. These r...Continue Reading

References

Jan 1, 1992·Journal of Neurotrauma·J A Gruner
Sep 1, 1985·The Journal of Cell Biology·S A LewisN J Cowan
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jan 1, 1999·Journal of Neurotrauma·D K ResnickD W Marion
May 24, 2000·British Journal of Anaesthesia·G Burnstock
Aug 31, 2001·Journal of Neurotrauma·C D MillsC E Hulsebosch
Dec 28, 2002·Journal of Neuroscience Research·Vemuganti L Raghavendra RaoRobert J Dempsey
Apr 1, 2003·Annals of Neurology·Simone Di GiovanniAlan I Faden
Apr 10, 2004·Neuroreport·Daniel K ResnickRaghu Vemuganti

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Citations

Jan 21, 2014·Experimental Neurology·Stella Elkabes, Arnaud B Nicot
Feb 10, 2012·Molecular Neurodegeneration·Ping K Yip, Andrea Malaspina
Sep 18, 2008·Journal of Neuroscience Research·Nicolas LonjonFlorence E Perrin
Nov 1, 2008·Neurourology and Urodynamics·Lynn L WooMargot S Damaser
Jun 8, 2010·BMC Neuroscience·Justin R SiebertDennis J Stelzner
Jun 20, 2008·Reviews in the Neurosciences·Aysha Z AkhtarChad B Sandusky
Aug 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michela CampoloSalvatore Cuzzocrea
Sep 21, 2007·Journal of Neurophysiology·Nicolas P LapointePierre A Guertin
Jan 28, 2017·Molecular Neurobiology·Adib ZendedelCordian Beyer
Sep 15, 2012·Experimental and Therapeutic Medicine·Zhenghua HongDun Hong
May 15, 2018·International Journal of Molecular Sciences·Jure TicaAthanasios Didangelos

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