Abstract
Approaches to identify the perception of tinnitus in various animal models have been difficult to apply to mouse. As a result, mice have been underutilized to investigate the cellular, molecular, and genetic mechanisms underlying tinnitus. A recent study in guinea pigs identified a novel spontaneous behavior (unconditioned response), changes in movement during silent gaps, that identified a subgroup of animals presumably with tinnitus. Guinea pigs identified with tinnitus failed to "freeze" in response to silent gaps in sound. In the hope of developing a rapid and reliable assay for mice, we used a similar approach. C57BL/6J mice underwent three trials in which spontaneous movement was video recorded in the presence of white noise interrupted with six silent gaps. Movement metrics included velocity and body movement. Before the third trial, mice underwent either sham or noise exposure to induce hearing loss and tinnitus. Auditory brainstem responses before and after noise trauma confirmed normal hearing in sham-treated animals and hearing loss in the noise-exposed cohort. No differences in the various movement metrics were detected during the silent gaps either before or after sham/noise exposure. Variability in spontaneous mov...Continue Reading
References
Mar 1, 1988·The Laryngoscope·P J JastreboffC T Sasaki
May 13, 1999·Hearing Research·Q Y ZhengL C Erway
Oct 10, 2001·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·L P NoldusR A Tegelenbosch
Feb 24, 2006·Behavioral Neuroscience·Jeremy G TurnerDonald M Caspary
Apr 25, 2006·Brain Research·Robert Burkard
Aug 15, 2006·Hearing Research·Guang YangWei Sun
Jun 15, 2011·Journal of the Association for Research in Otolaryngology : JARO·Ryan J Longenecker, Alexander V Galazyuk
Mar 22, 2012·Journal of Neuroscience Research·Jeremy TurnerSusan Shore
Feb 16, 2013·Ear and Hearing·Iris H L MaesManuela A Joore
Nov 8, 2013·Journal of Neurophysiology·Ann E Hickox, M Charles Liberman
Nov 16, 2013·Noise & Health·Jennifer CampoloRichard Salvi
Jan 16, 2014·Health and Quality of Life Outcomes·Florian ZemanUNKNOWN Tinnitus Research Initiative database study group
May 16, 2014·Neural Plasticity·Wolfger von der Behrens
Oct 4, 2014·Frontiers in Neurology·Sarah H HayesRichard J Salvi
Oct 4, 2014·SpringerPlus·Ryan J LongeneckerAlexander V Galazyuk
Nov 2, 2014·Frontiers in Neurology·Amarins N HeeringaPim van Dijk
Mar 31, 2015·Ear and Hearing·Kris BoyenPim van Dijk
May 15, 2015·Frontiers in Neurology·Alexander Galazyuk, Sylvie Hébert
Sep 10, 2015·PloS One·Laetitia Mwilambwe-TshiloboMaria N Geffen
Jan 10, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Santosh Kumar SwainMahesh Chandra Sahu
Jun 2, 2016·Hearing Research·Abby McCormackDeborah Hall
Sep 2, 2016·Frontiers in Behavioral Neuroscience·Hong YuChristopher R Cederroth