PMID: 9438904Jan 24, 1998Paper

Changes in Staphylococcus aureus density and lesion severity after topical application of povidone-iodine in cases of atopic dermatitis

Journal of Dermatological Science
H AkiyamaJ Arata

Abstract

A case-control study was performed to examine the efficacy of 10% povidone-iodine solution applied to atopic dermatitis patients. The density of Staphylococcus aureus on the eczematous lesions and the lesion severity before and after the topical application of povidone-iodine were compared. We found a 10-100-fold decrease in the density of S. aureus after povidone-iodine treatment in patients colonizing S. aureus at an initial density of > 1000 CFU/10 cm2. Erythema and exudation also decreased after povidone-iodine treatment in patients colonizing S. aureus at an initial density of > 1000 CFU/10 cm2. The 10% povidone-iodine solution disinfected S. aureus cells when added immediately after the cells were mixed in human plasma; however, 10% povidone-iodine solution only reduced the density of S. aureus cells by 10-100-fold when S. aureus cells were harvested after a 24 h incubation in human plasma. Staphylococcus aureus cells harvested after 24 h incubation in human plasma were often surrounded by fibrin bundles and cells circumscribed by fibrin bundles could not be disinfected with 10% povidone-iodine solution. We suggest that S. aureus cells may produce biofilm-like structures in atopic dermatitis patients and that these struct...Continue Reading

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Citations

Apr 23, 2003·Clinics in Dermatology·Marie Lodén
Jul 4, 1998·Journal of Dermatological Science·H AkiyamaJ Arata
Oct 5, 2002·Clinical Microbiology Reviews·Jan Faergemann
Aug 21, 2003·American Journal of Clinical Dermatology·Jann Lübbe
Jul 31, 2010·Immunology and Allergy Clinics of North America·Andreas Wollenberg, Christina Schnopp
May 21, 2008·International Journal of Cosmetic Science·K Halvarsson, M Lodén
Jun 15, 2011·The British Journal of Dermatology·N VlassovaG S Lazarus
Oct 28, 2003·The Journal of Dermatology·Anjum Singal, Gurvinder P Thami
Jan 16, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Masaaki KashiwamuraSatoshi Fukuda
Jul 19, 2018·Dermatologic Therapy·M MaaroufV Y Shi
Jul 28, 2017·The Journal of Dermatological Treatment·G KravvasF Al-Niaimi
Mar 24, 2010·Expert Opinion on Pharmacotherapy·Christina SchnoppMartin Mempel

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