PMID: 1214221Dec 1, 1975Paper

Changes in statistical release parameters during prolonged stimulation of preganglionic nerve terminals

The Journal of Physiology
E M McLachlan

Abstract

1. An analysis has been made of the release of acetylcholine (ACh) from the preganglionic nerve terminals of the isolated superior cervical ganglion of the guinea-pig during prolonged repetitive stimulation (10 Hz), using the amplitude of the excitatory post-synaptic potential (e.p.s.p.) as a measure of the amount of ACh released. 2. The decline in the mean amount of ACh released by each impulse over 20 min of continuous stimulation was accompanied by a small decrease in the mean miniature (min.) e.p.s.p. amplitude (less than 20%), both in the presence and absence of supplementary choline (3 x 10(-5) M). During stimulation in the presence of hemicholinium-3 (HC-3) (2 x 10(-5) M), the fall in min.e.p.s.p. amplitude was significantly larger. 3. Amplitude-frequency histograms of e.p.s.p.s evoked at different times after the beginning of stimulation were usually well predicted by binomial statistics, using the min.e.p.s.p.s released during each sample period as a measure of the quantal unit. In the other cases, histograms could be predicted using Poisson's Law. 4. A decline in quantal content, m, occurred in all experiments. In the presence of synthesis, with or without added choline, this was always associated with a decrease in t...Continue Reading

Citations

Jul 1, 1981·Journal of Biomedical Engineering·A J Hancox, D A Scrimshire
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·N TianR Nicoll
Jan 1, 1979·Neuroscience·H Zimmermann

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