Changes in structural and metabolic muscle characteristics following exercise-based interventions in patients with COPD: a systematic review

Expert Review of Respiratory Medicine
Jana De BrandtChris Burtin

Abstract

Patients with COPD suffer from lower-limb muscle dysfunction characterized by lower muscle oxidative capacity and muscle mass. Exercise-based training is expected to attenuate lower-limb intramuscular characteristics, but a detailed systematic approach to review the available evidence has not been performed yet. PUBMED and PEDro databases were searched. Twenty-five studies that implemented an exercise-based training program (aerobic and/or resistance training, high intensity interval training, electrical or magnetic stimulation) and reported muscle biopsy data of patients with COPD were critically appraised. The coverage of results includes changes in muscle structure, muscle protein turnover regulation, mitochondrial enzyme activity, oxidative and nitrosative stress, and inflammation after exercise-based training interventions. Study design and training modalities varied among studies, which partly explains the observed heterogeneous response in muscle characteristics. Gaps in the current knowledge are identified and recommendations for future research are made to enhance our knowledge on exercise training effects in patients with COPD.

References

May 1, 1992·Journal of Applied Physiology·A R CogganJ O Holloszy
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M Samarel
Feb 1, 1990·International Journal of Sports Medicine·H HowaldP Cerretelli
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·F MaltaisP LeBlanc
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·R GosselinkM Decramer
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·F MaltaisR Belleau
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·S BernardF Maltais
Dec 19, 1998·Journal of Cardiopulmonary Rehabilitation·J JobinC Simard
Jul 18, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·F C HagermanK E Ragg
Jul 18, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R S HikidaS Hervey
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·R A RabinovichJ Roca
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Arny A FerrandoRandall J Urban
Oct 18, 2002·Scandinavian Journal of Medicine & Science in Sports·R M CrameriJ R Sutton
Feb 1, 2003·European Journal of Applied Physiology·Luis Puente-MaestuWilliam W Stringer
Apr 4, 2003·American Journal of Respiratory and Critical Care Medicine·Annabelle CouillardChristian Préfaut
Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Didier SaeyFrancois Maltais
Dec 25, 2003·Muscle & Nerve·Regina M CrameriAdele Weston
Dec 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes D VeldhuisCyril Y Bowers
Feb 18, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P J AthertonH Wackerhage
Sep 2, 2005·The European Respiratory Journal·M Montes de OcaC Tálamo
Dec 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Harry R GoskerAnnemie M W J Schols
Apr 8, 2006·The American Journal of Clinical Nutrition·Erica P A RuttenAnnemie M W J Schols
Jul 11, 2006·Respiration; International Review of Thoracic Diseases·Roberto A RabinovichJosep Roca
May 8, 2007·Journal of Applied Physiology·Shlomit Radom-AizikIssahar Ben-Dov
Aug 4, 2007·Journal of Applied Physiology·Michael I LewisRichard Casaburi
Sep 19, 2007·Thorax·E BarreiroUNKNOWN ENIGMA in COPD project
Sep 22, 2007·European Journal of Clinical Investigation·T CrulM Decramer
Jun 17, 2008·Physiology·Marco Sandri
Nov 26, 2008·Free Radical Research·Víctor BustamanteEsther Barreiro
Feb 11, 2009·Medicine and Science in Sports and Exercise·UNKNOWN American College of Sports Medicine
Jan 30, 2010·The European Respiratory Journal·I VogiatzisS Zakynthinos
Feb 6, 2010·American Journal of Respiratory and Critical Care Medicine·Thierry TroostersRik Gosselink
Feb 20, 2010·Respiratory Medicine·Thierry TroostersMarc Decramer

❮ Previous
Next ❯

Citations

May 17, 2019·COPD·J Alberto NederDenis E O'Donnell
Apr 10, 2019·Journal of Clinical Medicine·Wai-Yan LiuMartijn A. Spruit
Sep 25, 2020·Advances in Nutrition·Clare McKeaveneyJoanne Reid
Jan 30, 2020·Frontiers in Physiology·Mathieu MarillierJ Alberto Neder
Aug 11, 2018·Medicine and Science in Sports and Exercise·Angèle N MerletLaurent A Messonnier
Feb 23, 2021·Respiratory Physiology & Neurobiology·G KaltsakasI Vogiatzis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses
Minjeong An, Marianne Shaughnessy
Journal of Burn Care & Research : Official Publication of the American Burn Association
Bernadette NedelecLorie A Kloda
© 2022 Meta ULC. All rights reserved