PMID: 6408218Jul 1, 1983Paper

Changes in testicular blood flow and testosterone production during aspermatogenesis after irradiation

The Journal of Endocrinology
J WangB P Setchell

Abstract

Exposure of the testes of anaesthetized adult rats to 527 rads of gamma-irradiation caused testis weight to fall slowly at first and then more rapidly from 21 days afterwards, reaching a minimum at 52 days, when spermatogenesis was severely disrupted. The weights of the accessory organs and the concentrations of testosterone in peripheral blood were slightly reduced; the concentrations in blood from the testicular veins were lower than control at shorter intervals after irradiation, but at later times tended to be similar or greater than control. Testicular blood flow per testis followed testis weight closely, and as a result the production of testosterone by the smaller testes (calculated as the product of plasma flow and the veno-arterial difference in testosterone concentration) was markedly reduced especially when the rats had been stimulated with human chorionic gonadotrophin (hCG). Serum FSH and LH rose appreciably as testis weight fell but there was a proportionately greater rise in FSH than LH, in comparison with surgically castrated animals. Increased amounts of extratubular, extracellular fluid were found in the aspermatogenic testes, but injection of hCG still caused increases in capillary permeability and the amount...Continue Reading

Citations

Jan 1, 1987·Journal of Steroid Biochemistry·J M SaezM A Rivarola
Jan 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M A Izard
Jul 1, 1988·Molecular and Cellular Endocrinology·G Pinon-LatailladeB Jégou
May 22, 2003·Reproductive Toxicology·Marvin L MeistrichKaren L Porter
Apr 1, 1991·International Journal of Andrology·P J O'ShaughnessyB M Cattanach
Jul 11, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·G ChaturapanichC Pholpramool
May 6, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Juha J HulmiAntti A Mero
Feb 1, 1988·International Journal of Andrology·K A Galil, B P Setchell
Jul 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·O K SchlappackJ A Stanley
Feb 1, 1986·Clinics in Endocrinology and Metabolism·R M Sharpe
Dec 3, 2011·Biology of Reproduction·Brian P Setchell
Nov 25, 2005·Endocrinology·Karen L PorterMarvin L Meistrich
Mar 14, 2003·Journal of Andrology·Marvin L Meistrich, Gunapala Shetty
Mar 17, 2011·Reproductive Medicine and Biology·Kohei Yamaguchi, Masato Fujisawa
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S J HowellS M Shalet

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