Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis

International Immunopharmacology
Sanam DolatiMehdi Yousefi

Abstract

MS is a chronic inflammatory disease that causes to brain inflammation and Th17 cells are considered to be important in multiple sclerosis pathogenesis. In the current study, we aimed to identify nanocurcumin effects on Th17 cells frequency, cytokines secretion, and expression of transcription factor of patients with relapsing-remitting multiple sclerosis (RRMS). In this study we investigated frequency of Th17 lymphocytes; the expression of transcription factor, associated cytokines and the concentration of them in 35 healthy controls, and from 25 patients at baseline and after 6 months of nanocurcumin treatment and also from 25 patients whose received placebo by flowcytometry, real-time PCR and ELISA, respectively. Our analysis revealed that the proportions of Th17 were increased dramatically, along with increases in the levels of IL-17A, IL-23, and RORγt expression in MS patients in compared with healthy control group. Post-treatment evaluation of the nanocurcumin group revealed a significant decrease in Th17 associated parameters such as Th17 frequency (p = 0.029), expression levels of RORγt (p < 0.0001) and IL-17 (p = 0.0044) and also secretion level of IL-17 (p = 0.0011), but IL-23 mRNA expression levels and IL-23 concentr...Continue Reading

Citations

Feb 26, 2019·Journal of Cellular Biochemistry·Mehrzad HajialiloMehdi Yousefi
Oct 15, 2019·Journal of Biomaterials Science. Polymer Edition·Priscila Veloso da Silva, Alvaro Antonio Alencar de Queiroz
Nov 7, 2019·Biological Trace Element Research·Sanam DolatiMehdi Yousefi
Sep 15, 2020·Journal of Cellular Physiology·Armin SadeghiMajid Ahmadi
May 6, 2019·Nutrients·Melissa YangChandra Mohan
Nov 6, 2020·Growth Factors·Sanam DolatiSeyed Kazem Shakouri
Dec 30, 2020·Journal of Cellular Physiology·Safa TahmasebiMajid Ahmadi
Aug 31, 2020·Multiple Sclerosis and Related Disorders·Morteza IzadiMajid Ahmadi
Apr 1, 2021·Life Sciences·Safa TahmasebiLeila Roshangar
Jun 17, 2021·Phytotherapy Research : PTR·Khadijeh KhezriAbbas Seyed Zakaryaei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Sanam DolatiMehdi Yousefi
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Kamel HamzaouiAgnes Hamzaoui
Biochemical and Biophysical Research Communications
Bin ZhangGuoen Fang
© 2022 Meta ULC. All rights reserved