PMID: 2500769Jan 1, 1989Paper

Changes in the alveolar connective tissue of the ageing lung. An immunohistochemical study

Virchows Archiv. A, Pathological Anatomy and Histopathology
A D'ErricoA M Mancini

Abstract

The modifications of the extracellular matrix (ExM) components in the alveolar parenchyma of elderly subjects were investigated using a panel of polyclonal antibodies. The elastic fibers showed a notable decrease along the alveolar walls while type III collagen increased when compared with that of non-elderly controls. No variations of these components were detectable in the alveolar ducts or in the respiratory bronchioli. An increase in the thickness of the alveolar basement membranes was detected in some of the subjects when antibodies against type IV collagen and laminin were used, while antibodies to fibronectin and type V collagen did not reveal any modifications compared with the controls. The modifications revealed in the lungs of the elderly can be related to the alterations of the elastic recoil and pulmonary compliance observed in these subjects.

References

Jul 1, 1977·Journal of Gerontology·S YasuokaE Tsubura
Feb 1, 1975·Chest·W M Thurlbeck, G E Angus
Nov 1, 1973·Journal of Applied Physiology·I AstrandA Kilbom
Dec 1, 1968·Journal of Applied Physiology·J M TurnerM E Wohl
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jun 1, 1981·American Journal of Clinical Pathology·S M HsuH Fanger
Jan 1, 1983·The American Journal of Surgical Pathology·A Churg
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F B BianchiS Garbisa
Jan 1, 1983·Gerontology·L AndreottiS Sampognaro
Jul 1, 1983·Journal of Clinical Pathology·A J D'ArdenneM K Bennett
May 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·E S BROWN
Oct 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·A M BRISCOEJ H McCLEMENT

❮ Previous
Next ❯

Citations

Jul 10, 2009·Age·Michael J Sherratt
Sep 29, 2001·The European Journal of Neuroscience·J M SerotG C Faure
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pierantonio LavenezianaDenis E O'Donnell
Nov 14, 2013·Multidisciplinary Respiratory Medicine·Gustavo Bittencourt CamiloAgnaldo José Lopes
Aug 20, 2010·Radiology·David M Hansell
Jan 1, 1999·Chest·E D Chan, C H Welsh
Jan 16, 2015·American Journal of Respiratory and Critical Care Medicine·Victor J ThannickalG R Scott Budinger
Jun 25, 2015·Revista da Associação Médica Brasileira·Tuncay YumrutepeSuleyman Savas Hacievliyagil
Aug 21, 2007·Experimental Gerontology·Carmen CalabresiCarlo Vergani
Mar 5, 2003·Clinics in Sports Medicine·Jonathon Truwit
May 13, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Yoshio YamamotoYoshitaka Suzuki
Dec 8, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Corry-Anke BrandsmaWim Timens
Mar 19, 2003·Drugs & Aging·Joël Belmin, Paul Valensi
Dec 14, 2012·Expert Review of Respiratory Medicine·Pierantonio LavenezianaDenis E O'Donnell
Aug 21, 2019·The Journal of Physiology·D A T NguyenA L Hudson
Nov 16, 2019·Annual Review of Physiology·Soo Jung Cho, Heather W Stout-Delgado
May 29, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Roy R WoldhuisCorry-Anke Brandsma
Dec 24, 2019·Frontiers in Physiology·Henri SchulteChristina Brandenberger
May 14, 2003·Virchows Archiv : an International Journal of Pathology·Angela PucciMarco Forni
Mar 10, 2017·Frontiers in Physiology·Denis E O'DonnellJ Alberto Neder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.