Changes in the antibacterial activity of melanin-bound drugs

Ophthalmic Research
M Fukuda, K Sasaki

Abstract

Affinity to melanin and changes of antibacterial activity of melanin-bound drugs were examined in 11 drugs, all of which showed an affinity for melanin. The highest melanin-binding ratio was seen in aminoglycosides. Among these, sisomicin sulfate (SISO) had the highest binding ratio (95.5%). The melanin-binding ratios seen in sulbenicillin sodium (SBPC), cephalosporins and fluoroquinolones were relatively low during the early phase of the reaction, but increased with time. The highest ratio seen in cefazolin sodium was 60.1%. Melanin-bound aminoglycosides showed a reduction in their antibacterial activity with both Bacillus subtilis and Escherichia coli. The reduction rate in the antibacterial activity of melanin-bound SISO against B. subtilis was 50.0% and that against E. coli was 43.0%. No changes in antibacterial activity were seen in the other 6 drugs bound to melanin.

Citations

Mar 1, 1995·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·K MochizukiY Ohnishi
Oct 27, 2006·Antimicrobial Agents and Chemotherapy·Joshua D Nosanchuk, Arturo Casadevall
Sep 6, 2003·The Journal of Pharmacy and Pharmacology·Chiho Ono, Makoto Tanaka
Apr 22, 2015·Antimicrobial Agents and Chemotherapy·Ludmila Matos BaltazarPatrícia Silva Cisalpino
Jan 10, 2020·International Ophthalmology·Silvia BartollinoCiro Costagliola
Aug 6, 2020·International Journal of Molecular Sciences·Marisa PalazzoCiro Costagliola
Feb 2, 2021·Critical Reviews in Food Science and Nutrition·Swarup Roy, Jong-Whan Rhim
Apr 4, 2021·Journal of Fungi·Sichen LiuJoshua D Nosanchuk

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