PMID: 22586906May 17, 2012Paper

Changes in the antioxidant system and level of proinflammatory cytokin IL-1beta in the blood patients of sufferi

Fiziolohichnyĭ zhurnal
N V FartushokO Ya Sklyarov

Abstract

Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and superoxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1beta).

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