Changes in the blood level, efficacy, and safety of tacrolimus in pregnancy and the lactation period in patients with systemic lupus erythematosus

Y HiramatsuS Arawaka


We investigated the efficacy and safety of tacrolimus (TAC) by monitoring its serum concentration for mothers and infants in pregnant patients with systemic lupus erythematosus (SLE). We measured trough concentrations of TAC in 25 pregnant patients with SLE to assess influence of TAC on the disease activity. Additionally, we measured the concentrations of TAC in umbilical arterial blood, breast milk, and breastfed infants to investigate the safety of TAC for the mothers and infants. The trough concentrations of TAC in the mothers significantly decreased in the second trimester as compared with those before pregnancy. However, the decrease in the trough concentrations of TAC did not lead to the deterioration of SLE. When examined, the doses of TAC were significantly lower in the second trimester and postpartum in the deteriorating group than those in the non-deteriorating group. There were no adverse events by TAC in mothers and fetuses. The concentrations of TAC in the umbilical cord blood were lower than those in the maternal blood. The relative infant dose in breastfed infants of TAC was < 1%. The level of TAC in infant bloods was below detectable limits. These findings suggest that TAC is one of the most effective and safest...Continue Reading


Mar 7, 2000·Current Medicinal Chemistry·F J Dumont
May 30, 2003·The Annals of Pharmacotherapy·Amy E FrenchGideon Koren
Oct 16, 2004·Lupus·G Ruiz-Irastorza, M A Khamashta
Feb 2, 2006·Obstetrics and Gynecology·Sharon J Gardiner, Evan J Begg
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Kam Hon Yoon
Feb 26, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Debra L BogenKatherine L Wisner
Jan 27, 2012·Clinical Rheumatology·Miguel A SaavedraLuis J Jara
Aug 22, 2012·Nature Reviews. Rheumatology·Aisha Lateef, Michelle Petri
Sep 26, 2012·Therapeutic Drug Monitoring·Songmao ZhengMary F Hebert
Jan 1, 2013·Transplantation·Mary F HebertThomas R Easterling
Jan 26, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Kate BramhamCatherine Nelson-Piercy
Mar 27, 2013·British Journal of Clinical Pharmacology·Songmao ZhengMary F Hebert
Sep 2, 2014·The Tohoku Journal of Experimental Medicine·Yasumori IzumiKiyoshi Migita
Jun 22, 2015·Transplantation Proceedings·S AktürkK Keven
Jun 23, 2015·Annals of Internal Medicine·Jill P BuyonJane E Salmon
Oct 3, 2015·Autoimmunity Reviews·Jennifer HannahDavid D'Cruz
Sep 19, 2016·European Journal of Medical Genetics·Antonio Perez-AytesMaximo Vento
Nov 3, 2017·Journal of Immunology Research·Sylvia J KroeseRuth D E Fritsch-Stork

❮ Previous
Next ❯


Jun 7, 2019·Current Opinion in Rheumatology·Luis J JaraMiguel A Saavedra
Sep 5, 2020·Expert Opinion on Drug Safety·Giuseppe LopalcoFlorenzo Iannone
Aug 7, 2021·Journal of Pharmaceutical and Biomedical Analysis·Fengbo WuMin Cai

❮ Previous
Next ❯

Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.