PMID: 11341485May 9, 2001Paper

Changes in the cAMP-related signal transduction mechanism in postmortem human brains of heroin addicts

Journal of Neural Transmission
S ShichinoheT Saito

Abstract

Immunoreactivities of adenylyl cyclase (AC) type I (AC-I), and basal, forskolin- and Mn2+-stimulated AC activities with or without calcium and calmodulin (Ca2+/CaM) were estimated in temporal cortex (TC)-and nucleus accumbens (NAc) membranes from brains of heroin addicts and controls. Immunoreactivity of AC-I was significantly decreased in TC from brains of heroin addicts, but that did not change in NAc. Ca2+/CaM-sensitive AC activity was significantly lower in TC from brains of heroin addicts, but that activity in NAc did not show significant difference compared with the control. Some previous reports demonstrated that Ca2+/CaM-sensitive AC activity in membranes from postmortem human brain reflected the function of AC-I. Therefore, the downregulation of AC-I in TC plays an important role in the molecular mechanism of chronic opiate addiction in human brain.

Citations

Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bruce T HopeRoy A Wise
Oct 16, 2010·Neuropathology and Applied Neurobiology·A Büttner
Jun 5, 2013·Alcoholism, Clinical and Experimental Research·Ratna GuptaMasami Yoshimura
Jan 28, 2010·Alcoholism, Clinical and Experimental Research·Mohammad Hasanuzzaman, Masami Yoshimura
Sep 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Norma C Alonzo, Barbara M Bayer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

© 2021 Meta ULC. All rights reserved