Changes in the D1 receptor-adenylate cyclase complex after priming

European Journal of Pharmacology
M MorelliG Di Chiara

Abstract

The D1 agonist, SKF 38393, failed to induce contralateral turning in drug-naive rats lesioned unilaterally with 6-hydroxydopamine from 17 days. Priming with a dopamine agonist, such as the D2 agonist, LY 171555, three days before, made SKF 38393 fully effective in inducing contralateral turning. Analysis of D1 receptor binding in striata of drug-naive and primed rats showed no change in the Bmax and Kd. In contrast, dopamine-stimulated adenylate cyclase showed a decrease in its Km for dopamine in the lesioned side of primed rats as compared with drug-naive rats. Thus, priming appears to elicit changes at the level of the transduction mechanism of D1 receptors rather than in the D1 recognition site itself.

References

Mar 1, 1979·Journal of Neuroscience Methods·A HellerC Fernandez
Mar 21, 1989·European Journal of Pharmacology·M MorelliG Di Chiara
Feb 5, 1985·European Journal of Pharmacology·T M DawsonJ K Wamsley
Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell

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Citations

Oct 2, 1991·European Journal of Pharmacology·A Hamdi, R M Kostrzewa
Apr 22, 1996·European Journal of Pharmacology·S Fox, J Brotchie
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·R M Kostrzewa, R Brus
Jul 1, 1997·Neuroscience and Biobehavioral Reviews·M Morelli
Jul 26, 2015·Progress in Neurobiology·Matthieu F BastideErwan Bézard
Jul 19, 2000·Journal of Neurophysiology·K J BlackJ S Perlmutter

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