PMID: 9184849Apr 1, 1997Paper

Changes in the distribution of integrins and their basement membrane ligands during development of human thyroid follicular epithelium

The Histochemical Journal
J LohiI Virtanen

Abstract

Interactions between cells and basement membrane components are crucial for the regulation of epithelial cell differentiation and polarization. We have studied by immunohistochemical methods the distribution of integrin adhesion proteins and some of their basement membrane ligands in foetal (16-19 weeks) and adult thyroid follicular epithelia. A diffuse immunoreactivity for only alpha 3, alpha v and beta 1 integrins was found in foetal follicular epithelium, whereas in adult follicular epithelium these integrins were expressed basally in a polarized manner. Additionally, beta 3 integrin was seen in a more basolaterally confined manner in adult follicular epithelium. Among basement membrane components, laminin alpha 1, beta 1, gamma 1 and beta 2 chains were found in epithelial basement membranes of the foetal thyroid gland, suggestive of the presence of laminins-1 and -3. In contrast, the basement membranes of adult follicular epithelium presented a much weaker immunoreactivity for the laminin beta 2 chain. Furthermore, immunoreactivity for the laminin alpha 2 chain was occasionally seen in adult thyroid glands, apparently confined to myofibroblasts. Immunoreactivity for type IV collagen alpha 1 and alpha 2 (IV) chains was found...Continue Reading

Citations

Jul 25, 2000·Thyroid : Official Journal of the American Thyroid Association·A MartinT F Davies
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·T Di MatolaM Vitale
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·J Lohi
Jul 23, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Noora PetäjäniemiIsmo Virtanen
Dec 9, 2000·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·W WeiC Chun-Peng
Jan 15, 2004·Experimental Cell Research·Hironobu FujiwaraKiyotoshi Sekiguchi

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