PMID: 8966752Jan 1, 1996Paper

Changes in the effect of Cd2+ on the respiration of isolated rat liver mitochondria after their preincubation with Ca2+, Sr2+, Ba2+, Mn2+ and ruthenium red

Tsitologiia
S M Korotkov, I A Skul'skiĭ

Abstract

Action of Cd+ on mitochondrial respiration is decreased by some bivalent ions, however the reason of this still remains obscure. Change of Cd2+ action over a wide range of its concentrations on respiration of rat liver mitochondria in states 4, 3 and in the presence of 2, 4-dinitrophenol (DNP) after mitochondrial preincubation with Ca2+, Sr2+, Ba2+, Mn2+ or ruthenium Red (RR) was studied in vitro. In the control (experiments without preincubation), Cd2+ lowers mitochondrial respiration in state 3 as well as that in the presence of DNP, and increases the respiration in state 4. However, the respiration is decreased if Cd2+ concentrations are more than 15 microM; in this case a short-term activation of respiration appears. In comparison with the control, it was demonstrated that the action of Cd2+ on mitochondrial respiration was enhanced in experiments with Ca2+, decreased in experiments with Sr2+ and Mn2+, and did not vary practically in experiments with Ba2+. The activation of respiration in state 4 is increased in experiments with Ca2+ and is absent with Mn2+. Different changes in Cd2+ action on mitochondrial respiration in experiments with Me2+ ions are associated with their influence on mitochondrial membrane permeability, ...Continue Reading

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