PMID: 1191777Apr 1, 1975Paper

[Changes in the electric activity of the myocardial fibers of the guinea pig during local anaphylactic reactions under conditions of inactivation of "rapid" sodium channels].

Biulleten' eksperimental'noĭ biologii i meditsiny
V B Ignat'evaB I Khodorov

Abstract

Changes of electrical activity (intracellular records) of guinea pig heart auriculus were studied during experimental cardiac anaphylaxis (ovalbumine being used as an antigen). Fast Na channels of the myocardial fibers having been depressed by long-standing depolarization in K+-rich (20 mM) Tyrode solutions, only the low-amplitude slow responses to brief stimuli were recorded. Addition of ovalbumine (2.10(-4) g/ml), histamine (1.10(-4) g/ml) or adrenaline (5.10(-6) g/ml) to the K-rich solution led to increase of both the amplitude and the duration of the responses. These data supported the hypothesis on the principal role of slow Na--Ca channels in the mechanism of the changes in the electrical activity of the myocardial fibers during cardiac anaphylaxis.

References

Jan 1, 1969·Pflügers Archiv : European journal of physiology·E Carmeliet, J Vereecke
Jan 1, 1973·Progress in Biophysics and Molecular Biology·H Reuter
Jan 1, 1971·Pflügers Archiv : European journal of physiology·D Mascher
Oct 1, 1971·Biulleten' eksperimental'noĭ biologii i meditsiny·B I KhodorovV B Ignat"eva
Jan 1, 1970·Pflügers Archiv : European journal of physiology·R Ochi
Jan 1, 1969·Pflügers Archiv : European journal of physiology·G VassortY M Gargouïl
Oct 1, 1966·Biulleten' eksperimental'noĭ biologii i meditsiny·I S Gushchin

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Citations

Jan 1, 1977·Journal of Neurochemistry·A G Tret'jakY P Kozlov
Jan 1, 1981·Neir̆ofiziologiia = Neurophysiology·V M BolotinaB I Khodorov
Mar 1, 1981·Neuroscience and Behavioral Physiology·B V Krylov, V S Makovskii
Jan 1, 1976·Neir̆ofiziologiia = Neurophysiology·G N MozhaevaIu A Neguliaev
Jan 1, 1986·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·N Piller, J Browning

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Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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