PMID: 9663435Jul 15, 1998Paper

Changes in the expression of extracellular matrix (ECM) and matrix metalloproteinases (MMP) of proliferating rat parotid acinar cells

Journal of Dental Research
R L BrovermanM G Humphreys-Beher

Abstract

Tissue morphogenesis, development, and maintenance of function are mediated by signals generated through the composition of the extracellular matrix. The regulation of the composition of matrix is determined by enzymes specific for their degradation, the matrix metalloproteinases. Chronic injections of the beta-adrenergic receptor agonist, isoproterenol, result in a non-neoplastic hypertrophy and hyperplasia of the rat parotid gland. The activity of matrix metalloproteinases, as measured by gelatin zymography and enzymatic digestion of Azocoll substrates by gland lysates, decreased significantly (P < 0.05) following 24 hrs of agonist treatment, and slowly recovered to control values by 6 days of treatment. Daily administration of the broad-spectrum matrix metalloproteinase inhibitor Galardin for 3 days in combination with isoproterenol resulted in enhanced gland hypertrophy compared with that produced by isoproterenol alone. Given alone, Galardin also caused hypertrophy. The relative abundance of mRNA for the extracellular matrix molecules, collagens I and III and fibronectin, declined rapidly following the initiation of beta-agonist treatment in vivo, while laminin B1 and B2 mRNA levels increased initially before declining bel...Continue Reading

References

Apr 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·M G Humphreys-BeherN Cassisi
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Feb 1, 1984·Analytical Biochemistry·R ChaviraJ H Hageman
Apr 1, 1982·Developmental Biology·M Bernfield, S D Banerjee
Jun 1, 1994·Pathology, Research and Practice·S Sunardhi-Widyaputra, B Van Damme
Oct 1, 1993·Current Opinion in Cell Biology·B D Shur
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H Birkedal-HansenJ A Engler
Mar 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·R BuM G Humphreys-Beher
Aug 1, 1962·The American Journal of Physiology·C A SCHNEYER
May 25, 1974·Journal of Molecular Biology·B P Brandhorst, E H McConkey

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Citations

Feb 4, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Isabel M PortoRaquel F Gerlach
Mar 31, 2011·International Endodontic Journal·H MatsuiH Nakamura
Dec 27, 2005·Biochemical and Biophysical Research Communications·Teruki KishiHideki Taniguchi
Jan 16, 2015·Metabolic Brain Disease·Dominic SchombergDaniel Resnick
Aug 11, 2000·European Journal of Heart Failure·F G Spinale
Oct 23, 2014·Journal of Cellular Biochemistry·Yi ZhouChih-Ko Yeh
Nov 25, 2004·European Journal of Oral Sciences·Cristiane FuruseVera Cavalcanti de Araújo

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