Changes in the expression of fibroblast growth factor receptors mark distinct stages of chondrogenesis in vitro and during chick limb skeletal patterning

Developmental Dynamics : an Official Publication of the American Association of Anatomists
G SzebenyiJ F Fallon

Abstract

Members of the fibroblast growth factor (FGF) family of growth factors are key regulators of limb skeletal patterning and growth. Abnormal expression of FGFs or mutations in their receptors (fgfrs) result in skeletal disorders. Here we show that changes in the expression of fgfrs are intrinsic properties of differentiating cartilage. In mesenchymal micromass cultures differentiating into cartilage, as in ovo, fgfr 1 mRNA was found predominantly in undifferentiated, proliferating mesenchyme, fgfr 2 in precartilage cell aggregates, and fgfr 3 in differentiating cartilage nodules. Thus, our data suggest that switches in the expression of fgfr 1, 2, and 3 mRNAs are associated with phases of cartilage patterning both in vitro and in ovo, and mark distinct stages in the development of the limb skeleton.

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Citations

Aug 16, 2003·Bone·D P C RiceI Thesleff
Aug 13, 2004·Proceedings. Biological Sciences·H G E HentschelStuart A Newman
Jan 16, 2016·Growth Factors·Mehdi MoradiMohammad Hossein Nasr-Esfahani
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Jul 30, 2015·Genes & Development·David M Ornitz, Pierre J Marie

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