PMID: 3754873Jun 1, 1986Paper

Changes in the expression of oncogenes encoding nuclear phosphoproteins but not c-Ha-ras have a relationship to monocytic differentiation of HL 60 cells

The Journal of Cell Biology
Z S Brelvi, G P Studzinski

Abstract

HL 60 cells were subcloned into variants with different sensitivities to the differentiation-inducing effect of 1,25 dihydroxyvitamin D3 (1,25(OH)2D3), as shown by increased oxidative and phagocytic activity and the appearance of cytoplasmic alpha-naphthyl butyrate esterase. Brief treatment (4 h) with 1,25(OH)2D3 or 5-azacytidine (5-Aza CR) of sensitive sublines induced monocytic differentiation in a fraction of treated cells. The phenotypic differentiation induced by 1,25(OH)2D3 was preceded by altered expression of oncogenes c-myc and c-fos, but not of c-Ha-ras or of the constitutively expressed p72 gene. Treatment with 5-Aza CR had similar effects but in addition increased the rate of transcription of the c-Ha-ras oncogene. In partially resistant sublines exposure to 1,25(OH)2D3 or 5-Aza CR resulted in changes in the levels of c-myc and c-fos mRNA, but the expression of c-Ha-ras gene did not correlate with the phenotypic differentiation. When induction of differentiation in responsive cells was delayed by cycloheximide, a temporal correlation could be made between changes in the expression of the c-myc gene and differentiation. These results suggest that a reduction of the elevated levels of c-myc gene transcription in HL 60...Continue Reading

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Citations

Jul 1, 1993·Journal of Cellular Physiology·S S Kolla, G P Studzinski
Apr 13, 1989·The New England Journal of Medicine·H ReichelA W Norman
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A Lomri, R Baron
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M YoshidaN Saijo
Jun 1, 1994·Leukemia & Lymphoma·S KumakuraT Tsunematsu
Aug 5, 2015·Journal of Clinical Medicine·Elzbieta Gocek, George P Studzinski
May 15, 1992·Analytical Biochemistry·C G TepperG P Studzinski
Nov 1, 1992·Critical Reviews in Oncology/hematology·M A Lea
Nov 1, 1989·Cell and Tissue Kinetics·G P Studzinski
Jan 1, 1993·Differentiation; Research in Biological Diversity·A Hultgårdh-NilssonN R Ringertz
Apr 29, 2016·Journal of Cellular Biochemistry·Elżbieta Gocek, George P Studzinski
Apr 1, 1987·Journal of Cellular Physiology·Z S Brelvi, G P Studzinski
May 18, 2000·Biochemical and Biophysical Research Communications·H YamanakaY Nakashima
Dec 3, 1993·Biochemical Pharmacology·M K Ritke, J C Yalowich

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