PMID: 2503391Jul 1, 1989Paper

Changes in the expression of specific Müller cell proteins during long-term retinal detachment

Experimental Eye Research
G P LewisS K Fisher

Abstract

Retinal detachments were produced in domestic cats by injecting fluid between the retinal pigment epithelium and neural retina. Retinas were allowed to remain detached for 30 or 60 days at which time the animals were killed. Tissue areas from detached and attached retinal regions from the same eye were processed for correlative biochemical and structural analysis, i.e. SDS-PAGE and Western blots of tissue homogenates were correlated with tissue processed for postembedding immunoelectron microscopy. Antibodies to six proteins were used as probes. Glial fibrillary acidic protein in Müller cells has previously been shown to increase after retinal detachment; here we show that vimentin, another intermediate filament protein present in Müller cells, also increases after detachment. In contrast, cellular retinaldehyde binding protein, cellular retinol binding protein, glutamine synthetase, and carbonic anhydrase C--all normally found in Müller cells--decrease after detachment. The results of this study indicate that retinal Müller cells dramatically alter their expression of proteins in response to retinal detachment.

References

Jul 1, 1977·American Journal of Ophthalmology·J G ClarksonD Massof
Sep 1, 1977·The British Journal of Ophthalmology·N F Johnson, W S Foulds
Oct 8, 1985·The Journal of Comparative Neurology·J Schnitzer
Dec 1, 1988·Experimental Eye Research·G P LewisS K Fisher
Dec 1, 1988·Experimental Eye Research·G P LewisS K Fisher
Jan 1, 1987·Experimental Eye Research·P A EricksonD D Kaska
Oct 15, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·R H Steinberg
Sep 1, 1985·Experimental Eye Research·A J EisenfeldJ C Saari
Jan 1, 1967·Histochemie. Histochemistry. Histochimie·H P Hansson
Oct 1, 1971·The Journal of Cell Biology·M M Lavail, L Reif-Lehrer
Nov 1, 1972·Biological Reviews of the Cambridge Philosophical Society·M J Carter
Jun 1, 1984·Ophthalmology·R C Eagle
Feb 1, 1984·European Journal of Biochemistry·J Ciesielski-TreskaD Aunis
Sep 1, 1983·The Journal of Cell Biology·A H Bunt-Milam, J C Saari
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E WangR K Liem
Jan 1, 1983·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E Lütjen-DrecollM Eichhorn
Nov 10, 1981·The Journal of Comparative Neurology·N M Miller, M Oberdorfer
Mar 1, 1959·Archives of Biochemistry and Biophysics·P K DATTA, T H SHEPARD
Jul 1, 1962·The Journal of Cell Biology·J E DOWLING, R L SIDMAN
May 1, 1960·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T KUWABARA, D G COGAN

❮ Previous
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Citations

Jan 1, 1994·Documenta Ophthalmologica. Advances in Ophthalmology·G Calogero, B Ricci
Jan 15, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stephanie C JoachimFranz H Grus
Sep 26, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Olga KlebanovArieh S Solomon
Aug 1, 1995·Experimental Eye Research·K A RichJ C Blanks
Feb 1, 1997·Neurochemistry International·J P WoodN N Osborne
Feb 5, 2003·Neuroscience Letters·Bong Keun SongEldon E Geisert
Aug 2, 2003·Progress in Retinal and Eye Research·Robert E MarcEnrica Strettoi
Oct 26, 1999·Progress in Retinal and Eye Research·M Kalloniatis, G Tomisich
May 16, 2002·Clinical & Experimental Ophthalmology·Kathy H C WuFrancis A Billson
Aug 1, 1993·The European Journal of Neuroscience·E Rungger-BrändleH M Eppenberger
Mar 19, 2003·The British Journal of Ophthalmology·S M S Ghazi-NouriD G Charteris
May 13, 2008·Investigative Ophthalmology & Visual Science·Mark R VerardoSteven K Fisher
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·E N GrigoryanV I Mitashov
Oct 23, 2002·Journal of Neurochemistry·Iftach ShakedLily Vardimon
Nov 12, 2005·Current Eye Research·Arnd GandorferPhilip Luthert
Mar 22, 1991·The Journal of Comparative Neurology·S L Semple-Rowland
Mar 27, 2012·Micron : the International Research and Review Journal for Microscopy·Tapas Chandra Nag, Shashi Wadhwa
Mar 14, 2012·Micron : the International Research and Review Journal for Microscopy·Tapas Chandra Nag, Shashi Wadhwa
Aug 8, 2009·Progress in Retinal and Eye Research·Andreas BringmannAndreas Reichenbach
Dec 31, 2008·Neurochemistry International·Andreas BringmannAndreas Reichenbach
Oct 24, 2015·Experimental Eye Research·Jennifer L ThomasRyan Thummel
Oct 2, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mário Cesar do Nascimento BevilaquaKarin C Calaza
Jul 18, 2008·Journal of Neuroscience Methods·Stefanie KaempfGabriele Thumann
May 27, 2015·Archivos de la Sociedad Española de Oftalmología·V M Asensio-SánchezM Cantón
Nov 21, 2007·Journal of Cellular Biochemistry·Sofía GarcíaAna María López-Colomé
Nov 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David L Stocum, Günther K H Zupanc
Sep 21, 2011·The European Journal of Neuroscience·Günther K H Zupanc, Ruxandra F Sîrbulescu
Jan 26, 2013·The Journal of Comparative Neurology·Jacqueline ChuaMichael Kalloniatis
Apr 24, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nathan J CooreyMark C Gillies
Feb 15, 2005·Progress in Retinal and Eye Research·Steven K FisherMark R Verardo
Sep 1, 2004·Experimental Eye Research·Caroline LupienChristian Salesse
Aug 1, 1990·Experimental Eye Research·P A EricksonS K Fisher

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