PMID: 9420217Jan 7, 1998Paper

Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation, and macrophage tropism but not replication, cytopathicity, or CCR-5 coreceptor recognition

Journal of Virology
L M RudenseyJulie Overbaugh

Abstract

Simian immunodeficiency virus SIVMne, like human immunodeficiency virus, evolves from a macrophage-tropic, non-syncytium-inducing virus at early times in infection to a T-cell-tropic, syncytium-inducing, cytopathic virus population over the course of progression to AIDS. Because the viruses isolated late in SIVMne infection of macaques include a complex mixture of variants, the viral determinants of such phenotypic changes have not been defined. To identify genetic changes that are important to virus evolution in the host, we constructed chimeric viruses by introducing variant envelope genes representative of proviruses throughout the course of infection and disease into the SIVMne parental clone (SIVMneCL8) that infected the macaque. The chimeric viruses expressed sequences encoding the surface unit of the envelope glycoprotein (Env-SU) of variants cloned between 35 and 170 weeks postinfection. The chimera with Env-SU from 35 weeks postinfection encoded only four changes in V1 compared to SIVMneCL8, whereas the chimeras encoding Env-SU from variants isolated later in infection encoded progressively more mutations both in V1 and elsewhere. Like SIVMneCL8, the chimeras were infectious for CEMx174 cells and macaque peripheral blo...Continue Reading

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Citations

Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takeshi YamadaAikichi Iwamoto
Sep 15, 2004·Acta Microbiologica Et Immunologica Hungarica·Dalma Vödrös, Eva Mária Fenyö
Sep 30, 2015·AIDS·Keshet RonenJulie Overbaugh
Apr 3, 2001·AIDS Research and Human Retroviruses·I S FortgangL S Levy
May 5, 2004·Médecine sciences : M/S·Valérie CourgnaudPierre Sonigo
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Simon D W FrostDouglas D Richman
Jun 5, 1999·AIDS Research and Human Retroviruses·D C Montefiori, T G Evans
Nov 17, 2012·Nature Reviews. Microbiology·Theodora Hatziioannou, David T Evans
Feb 15, 2008·The Journal of General Virology·Benedikta S HaflidadóttirValgerdur Andrésdóttir
Mar 27, 2009·AIDS Research and Human Retroviruses·Susan M GrahamJulie Overbaugh
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·T IgarashiM Martin
Oct 5, 2005·PLoS Pathogens·Linda J DemmaSilvija I Staprans

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