PMID: 9662132Jul 14, 1998Paper

Changes in the fracture toughness of bone may not be reflected in its mineral density, porosity, and tensile properties

Bone
X D WangC M Agrawal

Abstract

Age-related changes in the skeleton often lead to an increase in the susceptibility of bone to fracture. Such changes most likely occur in the constituents of bone, namely, the mineral and organic phases, and in their spatial arrangement manifested as orientation and microstructure. In the past, however, bone loss or decline in bone mineral density has been considered to be the major contributing factor for the increased risk of bone fractures, and elastic modulus and ultimate strength have been commonly used to assess bone quality and strength. However, whether these properties provide sufficient information regarding the likelihood of bone to fracture remains debatable. Using a novel fracture toughness test, which measures the energy or stress intensity required to propagate a crack within a material, the objective of this study was to investigate if the mineral density and mechanical properties of bone can accurately predict bone fragility as measured by fracture toughness. Changes in fracture toughness (K(IC)), bone mineral density (BMD), elastic modulus (E), yield and ultimate strength (sigma y and sigma s), porosity (P0), and microhardness (Hv) of bone were examined as a function of age in a baboon model. With increasing ...Continue Reading

References

Dec 1, 1977·Nature·W Bonfield, M D Grynpas
Oct 1, 1976·Acta Orthopaedica Scandinavica·C B Smith, D A Smith
Jan 1, 1991·Journal of Biomechanics·R B Martin
Jan 1, 1991·Experimental Gerontology·G M Kiebzak
Jan 1, 1989·Journal of Biomechanics·J C Behiri, W Bonfield
Jan 1, 1987·Journal of Biomechanics·W Bonfield
Jan 1, 1988·Journal of Biomechanics·M B Schaffler, D B Burr
Jan 3, 1980·Nature·J L Katz
Nov 13, 1980·Nature·S Chatterji
Mar 1, 1995·Journal of Biomechanics·T L NormanD B Burr
Jan 1, 1993·Calcified Tissue International·S M Ott
Jan 1, 1994·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·X WangC M Agrawal

❮ Previous
Next ❯

Citations

Jan 16, 2007·Journal of Materials Science. Materials in Medicine·P MoranD Lyons
May 25, 2007·Current Osteoporosis Reports·Deepak Vashishth
Dec 14, 2007·Journal of Biomechanics·Victor KosmopoulosTony S Keller
May 19, 2006·Journal of Biomechanical Engineering·Jiahau YanJohn J Mecholsky
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C WüsterUNKNOWN KIMS Study Group and the KIMS International Board. Pharmacia & Upjohn International Metabolic Database
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S NuzzoF Peyrin
Jul 8, 2008·The Review of Scientific Instruments·Paul HansmaDavid Kohn
Jul 26, 2011·Journal of the Mechanical Behavior of Biomedical Materials·K J KoesterR O Ritchie
Oct 4, 2015·Journal of the Mechanical Behavior of Biomedical Materials·F G A SilvaM I R Dias
Oct 24, 2006·Journal of Biomechanics·Ani Ural, Deepak Vashishth
Jul 22, 2008·Journal of Medical Primatology·L M HavillM C Mahaney
Mar 22, 2006·Journal of Biomechanics·Jiahau YanRoger L Reep
Feb 3, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mathilde GrankeJeffry S Nyman
Dec 3, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wacharaporn TiyasatkulkovitJohn L VandeBerg
Jan 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·X WangC M Agrawal
Dec 24, 2011·Medical Engineering & Physics·Nicholas A RussellWilliam R Walsh
Feb 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xiaodu Wang, Qingwen Ni
Dec 27, 2005·Journal of Biomechanics·Ani Ural, Deepak Vashishth
Aug 4, 2009·International Journal of Oral and Maxillofacial Surgery·W-J SeongC-C Ko
Mar 4, 2014·Journal of Biomechanics·David MittonKarine Bruyère-Garnier
Jan 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Christopher J Hernandez, Marjolein Ch van der Meulen
Nov 2, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Yikun NiYubo Fan
May 5, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·David ChristenRalph Müller
Oct 19, 2005·Journal of Biomedical Optics·J W AgerR O Ritchie
Mar 5, 2008·Dento Maxillo Facial Radiology·A A FonsecaL P Carapeto
Aug 28, 1999·Journal of Biomechanical Engineering·S D PanteliouR Civitelli
Feb 29, 2000·Clinical Orthopaedics and Related Research·X WangC M Agrawal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.