Changes in the function of the inhibitory neurotransmitter system in the rat brain following subchronic inhalation exposure to 1-bromopropane

Neurotoxicology
S UenoH Hori

Abstract

1-Bromopropane (1-BP) has been widely used as a cleaning agent and a solvent in industries, but the central neurotoxicity of 1-BP remains to be clarified. In the present study, we investigated the effects of subchronic inhalation exposure to 1-BP vapor on the function of the inhibitory neurotransmitter system mediated by gamma-aminobutyric acid (GABA) in the rat brain. Male Wistar rats were exposed to 1-BP vapor for 12 weeks (6h/day, 5 days/week) at a concentration of 400 ppm, and, in order to investigate the expression and function of brain GABA type A (GABAA) receptors, total/messenger RNA was prepared from the neocortex, hippocampus, and cerebellum of the control and 1-BP-exposed rats. Moreover, hippocampal slices were prepared, and the population spike (PS) amplitude and the slope of the field excitatory postsynaptic potential (fEPSP) were investigated in the paired-pulse configuration of the extracellular recording technique. Using the Xenopus oocyte expression system, we compared GABA concentration-response curves obtained from oocytes injected with brain subregional mRNAs of control and 1-BP exposed rats, and observed no significant differences in apparent GABA affinity. On the other hand, paired-pulse inhibition of PS a...Continue Reading

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Citations

Dec 3, 2014·Toxicology and Applied Pharmacology·Zhenlie HuangGaku Ichihara
Jun 12, 2012·Toxicology and Applied Pharmacology·Zhenlie HuangGaku Ichihara
Sep 20, 2011·Toxicology and Applied Pharmacology·Zhenlie HuangGaku Ichihara
Apr 30, 2011·Toxicology·Sahabudeen Sheik MohideenShoji Nakamura
Apr 26, 2016·Journal of Occupational Health·Toru IshidaoHajime Hori

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