Changes in the Gastric Mucosa With Aging

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Amnon Sonnenberg, Robert M Genta

Abstract

We aimed to characterize age-related changes in the gastric mucosa and investigate the contribution of Helicobacter pylori infection to these changes. We collected data from a large national pathology database of 895,323 subjects who underwent esophagogastroduodenoscopy with gastric biopsies from January 2008 through December 2013 at endoscopy centers throughout the United States. The prevalence of various types of gastric histopathology was expressed as percent of the total study population, stratified by sex, age, and state. Over a lifetime, the gastric mucosa became abnormal in 50% of subjects. A higher proportion of people in areas with a high prevalence of H pylori infection acquired gastric abnormalities. H pylori-associated chronic active gastritis and mucosal changes caused by infection were observed in 22% of biopsies; these were the most common gastric abnormalities observed. Reactive gastropathy, which was detected in 18% of biopsies, increased with age and was the second most common factor of gastric pathology observed. On the basis of an analysis of biopsies collected by esophagogastroduodenoscopy in the United States, gastric abnormalities increase with age. Most pathologic conditions detected by histologic analys...Continue Reading

References

Oct 1, 1986·Gut·A Sonnenberg
Mar 1, 1993·Journal of Clinical Pathology·G M SobalaM F Dixon
Jul 3, 1998·Gastroenterology Clinics of North America·J R Saltzman, R M Russell
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth M BikDavid A Relman
Aug 31, 2006·Seminars in Diagnostic Pathology·Robert M Genta
Sep 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marin H Kollef
Jan 21, 2009·La Presse médicale·Thierry CotonMichel Guisset
Nov 28, 2009·Best Practice & Research. Clinical Gastroenterology·Nathalie Salles
Sep 29, 2011·Gastrointestinal Endoscopy Clinics of North America·Joanna A Gibson, Robert D Odze
Jan 10, 2012·Alimentary Pharmacology & Therapeutics·A Sonnenberg, R M Genta
Apr 11, 2012·Alimentary Pharmacology & Therapeutics·R M Genta, A Sonnenberg
Jun 23, 2012·The Veterinary Clinics of North America. Small Animal Practice·D P Laflamme
Aug 30, 2012·Alimentary Pharmacology & Therapeutics·I MaguilnikR M Genta
Jun 22, 2013·Alimentary Pharmacology & Therapeutics·A Sonnenberg

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Citations

Aug 18, 2016·Helicobacter·Mārcis LejaHermann Brenner
Mar 25, 2018·Journal of Digestive Diseases·Jing-Yuan FangUNKNOWN Chinese Society of Gastroenterology, Chinese Medical Association
Jul 20, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tomonori YanoManabu Muto
Jun 1, 2018·Case Reports in Gastrointestinal Medicine·Sandra Mabel Camacho-GomezNeelesh Ajit Tipnis
Aug 2, 2016·Canadian Journal of Gastroenterology & Hepatology·Anouar TeriakyBrian Yan
Jan 19, 2021·Scandinavian Journal of Gastroenterology·Taned ChitapanaruxNirush Lertprasertsuke
Dec 10, 2019·Gastroenterology·Osama AltayarReem A Mustafa
Mar 11, 2021·Gastroenterology Research and Practice·Jorge J Cruz-CruzMarcia Cruz-Correa
Jun 1, 2021·Gastrointestinal Endoscopy Clinics of North America·Robert J Huang, Joo Ha Hwang
Oct 9, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert J HuangJoo Ha Hwang

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