Changes in the Gut Microbiota of Urban Subjects during an Immersion in the Traditional Diet and Lifestyle of a Rainforest Village

MSphere
Kelly V RugglesMaria G Dominguez-Bello

Abstract

People living traditional lifestyles have higher gut microbiota diversity than urban subjects. We hypothesized that shifting lifestyles from an urban environment to a traditional rainforest village would lead to changes in the microbiota of visitors, which would become more similar to the microbiota of villagers. Here, we characterized at different time points the microbiota of 7 urban visitors (5 adults and 2 children) staying in a rainforest Amerindian village for 16 days and compared them with a reference collection of samples from age-matched local villagers. We performed a 16S rRNA gene survey of samples from multiple body sites (including fecal, oral, nasal, and skin samples) using Illumina MiSeq sequencing. The main factor segregating the microbiotas of each body site was the human group (i.e., visitors versus villagers), with the visitor microbiota tending to have lower alpha diversity; the lowered alpha diversity was statistically significant in the microbiota of skin and in the children's fecal and oral microbiota. During the rainforest period, all visitors experienced microbiota changes within their personal cloud of variation. For all body sites, the microbiota conformations in the visitor children better matched th...Continue Reading

References

Feb 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M BrulcBryan A White
Apr 7, 2010·Science Translational Medicine·Peter J TurnbaughJeffrey I Gordon
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Sep 10, 2010·The ISME Journal·Catherine LozuponeRob Knight
Nov 3, 2010·FEMS Microbiology Reviews·Dan KnightsRob Knight
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Jun 16, 2012·Nature·Tanya YatsunenkoJeffrey I Gordon
Jun 16, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicole de WitRoelof van der Meer
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Nov 14, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Karen P ScottSylvia H Duncan
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Apr 17, 2014·Nature Communications·Stephanie L SchnorrAlyssa N Crittenden
Jun 5, 2014·Nature·Sathish SubramanianJeffrey I Gordon
Dec 10, 2014·Nature Reviews. Endocrinology·Laura M Cox, Martin J Blaser
Apr 15, 2015·Parasite Immunology·P Loke, Y A L Lim
Jul 1, 2015·Nature Communications·Yael R NobelMartin J Blaser
Aug 1, 2015·Science Advances·Jose C ClementeM Gloria Dominguez-Bello
Jan 15, 2016·Nature·Erica D SonnenburgJustin L Sonnenburg
Jul 8, 2016·Nature·Justin L Sonnenburg, Fredrik Bäckhed
Oct 27, 2016·Nature Microbiology·Alexandra E LivanosMartin J Blaser
Aug 26, 2017·Science·Samuel A SmitsJustin L Sonnenburg
Sep 1, 2017·The World Allergy Organization Journal·Susan L PrescottDianne E Campbell
Oct 14, 2017·Science Advances·Keith A MartinezMaria G Dominguez-Bello
Nov 29, 2017·Nature Microbiology·Anjelique F SchulferMartin J Blaser

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Citations

Mar 14, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Sharon M Donovan
Mar 10, 2020·Advances in Nutrition·Tracey L K BearPramod K Gopal
Jan 27, 2019·Scientific Reports·Amanda PeBenitoMartin J Blaser
Aug 2, 2019·MSphere·Andres GomezSteven R Leigh
Nov 18, 2020·Development = Développement = Desarrollo·Ruchi Shroff, Carla Ramos Cortés
Apr 10, 2021·Leukemia·Mel GreavesAnthony Ford
May 31, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ziyu JiangJiege Huo

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Datasets Mentioned

BETA
ERP110254

Software Mentioned

R package vegan
LEfSe
QIIME pipeline
R package phyloseq

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