Changes in the heterogeneity of cerebral glucose metabolism with healthy aging: quantitative assessment by fractal analysis

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Jae Sung LeeMyung Chul Lee

Abstract

It has been shown that heterogeneity of cerebral glucose metabolism is increased in neuropsychiatric degenerative diseases. However, proper assessment of older patients requires knowledge about the effect of aging on heterogeneity. This study characterized the effects of aging on the heterogeneity of the distribution of cerebral glucose metabolism in healthy volunteers. Sixty-six healthy volunteers (age range, 19-75 years) underwent flurodeoxyglucose brain positron emission tomography (PET), and all the PET images were spatially normalized onto a previously segmented standard brain template to parcel the brain regions automatically. Fractal dimension was regarded as a quantitative measurement for the heterogeneity of cerebral glucose metabolism and obtained for 9 brain regions. Participants were subdivided into young/midlife and elderly groups, and the Student t test was applied to the comparison of fractal dimensions in those groups. Analysis of covariance was performed for each region to explore the effects of age, gender, age-by-gender interaction, and total counts in the brain on the observed metabolic heterogeneity. Fractal dimensions were higher for elderly volunteers in most brain regions. Differences between the 2 group...Continue Reading

Citations

Jul 22, 2015·Reviews in the Neurosciences·Ann M JohnCharles J Prestigiacomo
Feb 7, 2006·Nuclear Medicine and Biology·Douglas A MarstellerStephen L Dewey
Apr 24, 2015·PloS One·Tilo WinklerJose G Venegas
Dec 24, 2013·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Antonio Di IevaMiguel Martín-Landrove

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