Changes in the histaminergic system during vestibular compensation in the cat.

The Journal of Physiology
B TighiletM Lacour

Abstract

To determine how the histaminergic system is implicated in vestibular compensation, we studied the changes in histidine decarboxylase (HDC; the enzyme synthesizing histamine) mRNA regulation in the tuberomammillary (TM) nuclei of cats killed 1 week, 3 weeks and 3 months after unilateral vestibular neurectomy (UVN). We also used one- and two-step bilateral vestibular neurectomized (BVN) cats to determine whether HDC mRNA regulation depended on the asymmetrical vestibular input received by the TM nuclei neurons. In addition, we analysed the HDC mRNA changes in the TM nuclei and the recovery of behavioural functions in UVN cats treated with thioperamide, a pure histaminergic drug. Finally, we quantified binding to histamine H3 receptors (H3Rs) in the medial vestibular nucleus (VN) by means of a histamine H3R agonist ([3H]N-alpha-methylhistamine) in order to further investigate the sites and mechanisms of action of histamine in this structure. This study shows that UVN increases HDC mRNA expression in the ipsilateral TM nucleus at 1 week. This increased expression persisted 3 weeks after UVN, and regained control values at 3 months. HDC mRNA expression was unchanged in the one-step BVN cats but showed mirror asymmetrical increases ...Continue Reading

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Citations

Dec 1, 2007·The Journal of Physiology·Maria Vittoria PoddaClaudio Grassi
Aug 4, 2009·Annals of the New York Academy of Sciences·Michel LacourLiliane Borel
Oct 14, 2010·Journal of Clinical Pharmacology·Christine RedonLiliane Borel
Aug 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Mayank B Dutia
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Jul 2, 2011·Médecine sciences : M/S·Sophie DutheilBrahim Tighilet
Jul 3, 2020·Médecine sciences : M/S·Brahim TighiletChristian Chabbert
Jan 1, 2014·Cerebellum & Ataxias·Bin LiJian-Jun Wang
Jun 10, 2010·The Journal of Pharmacology and Experimental Therapeutics·F GbahouJ-M Arrang
Jan 19, 2019·Progress in Neurobiology·Brahim Tighilet, Christian Chabbert
Jan 20, 2007·Neuroscience Letters·Aline Cristina Piratello, Rosana Mattioli

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