Changes in the incidence and etiology of congenital hypothyroidism detected during 30 years of a screening program in central Serbia

European Journal of Pediatrics
Katarina MitrovicDragan Zdravkovic

Abstract

Congenital hypothyroidism (CH) is the most frequent congenital endocrine disorder. The purpose of the present study was to determine the incidence of CH in Central Serbia from 1983 to 2013. Newborn screening for CH was based on measuring neonatal thyroid-stimulating hormone (TSH) using a 30 mU/l cutoff (CO) until 12/1987 (P1), 15 mU/l until 12/1997 (P2), 10 mU/l until 12/2006 (P3), and 9 mU/l thereafter (P4). During the study period, there were 1,547,122 live births screened for CH. Primary CH was detected in 434 newborns, with incidence of 1:3728. With gradual lowering of the CO, the incidences of CH increased from 1:5943 in P1 to 1:1872 in P4 (p < 0.001). Incidence of CH with ectopic and enlarged gland doubled (p < 0.001), while prevalence of athyreosis remained relatively constant. The most prominent finding was the increase in the transient CH from none in P1 to 35 % of all CH patients in P4. The overall incidence of CH in Central Serbia during study period nearly tripled, with a significant increase in almost all etiological categories, and was associated with lowering TSH cutoffs as well as other yet unidentified factors. Further studies are needed to identify other factors associated with increasing incidence of CH. Cong...Continue Reading

References

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Citations

May 2, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kui DengYanping Wang
May 12, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Somchit JaruratanasirikulHutcha Sriplung
Sep 23, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Violeta Anastasovska, Mirjana Kocova
Aug 31, 2019·Paediatrics & Child Health·Ivana IvanisevicVera M Zdravkovic
Aug 21, 2017·International Journal of Neonatal Screening·Violeta AnastasovskaMirjana Kocova
Sep 23, 2018·Pediatrics·Niamh McGrathNuala P Murphy

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