Changes in the Lémann Index Values During the First Years of Crohn's Disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Cyrielle GillettaJacques Cosnes

Abstract

Stricturing or penetrating lesions develop over time in most patients with Crohn's disease. The Lémann Index indicates the degree of digestive damage at a given time in an individual. We tracked changes in Lémann Index scores in an inception cohort of patients and looked for factors associated with digestive damage. We studied 221 patients diagnosed with Crohn's disease from 2004 through 2011 who received 2 or 3 serial morphologic evaluations over a period of 2 to 10 years. We collected cross-sectional images and had them reviewed by a gastroenterologist and a radiologist; Lémann index scores were calculated. A value of 2 was chosen as the cut-off value for substantial transparietal damage. Factors associated with a score greater than 2 at the last evaluation and progression of index scores were identified using univariate analysis and logistic regression analyses. The median index Lémann Index scores were 2.3 (interquartile range [IQR], 1.2-3.9) at first evaluation, 3.5 (IQR, 1.2-8.6) at 2 to 5 years after diagnosis, and 8.3 (IQR, 1.2-12.1) at 5 to 10 years after diagnosis. Index scores increased significantly at each stage compared with initial or previous values (P < .0001). After 73 months (IQR, 51-96 mo) of follow-up evalu...Continue Reading

References

Jul 20, 2002·Inflammatory Bowel Diseases·Jacques CosnesJean-Pierre Gendre
Mar 6, 2012·Gut·Jacques CosnesPhilippe Seksik
Jun 19, 2012·Diseases of the Colon and Rectum·Tim W EglintonFrank A Frizelle

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Citations

Jan 9, 2016·Journal of Crohn's & Colitis·Gionata FiorinoSilvio Danese
Mar 24, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Bhavana Bhagya RaoDavid G Binion
Jun 18, 2016·Current Gastroenterology Reports·Jordi Rimola, Julián Panés
Jun 11, 2016·Journal of Crohn's & Colitis·Joana TorresJean-Frédéric Colombel
Jul 14, 2016·Expert Review of Gastroenterology & Hepatology·Naila ArebiSiwan Thomas-Gibson
Nov 1, 2016·Journal of Crohn's & Colitis·Uri Kopylov, Rami Eliakim
Nov 29, 2017·Journal of Crohn's & Colitis·Eyal KlangUNKNOWN Israeli IBD research Nucleus [IIRN)
Jul 25, 2017·Expert Review of Gastroenterology & Hepatology·Uri KopylovRami Eliakim
Apr 25, 2018·Therapeutic Advances in Gastroenterology·Noa RozendornEyal Klang
Aug 24, 2018·Journal of Crohn's & Colitis·Andreas SturmUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR
Sep 7, 2017·Gut·Silvio DaneseLaurent Peyrin-Biroulet
Jan 18, 2018·Diseases of the Colon and Rectum·Wei LiuQingwen Xie
Dec 10, 2015·Journal of Clinical Gastroenterology·Bhavana Bhagya RaoDavid G Binion
Apr 22, 2020·Expert Review of Gastroenterology & Hepatology·Salvatore CucchiaraLaura Stronati
May 10, 2016·Journal of Clinical Gastroenterology·Renée M Marchioni Beery, Joshua R Korzenik
Mar 28, 2020·United European Gastroenterology Journal·Gionata FiorinoSilvio Danese
Feb 23, 2020·Annals of Nuclear Medicine·João Batista Monteiro TajraLiliana Moscoso Ribeiro
Nov 7, 2018·World Journal of Clinical Cases·Elena Daniela Serban
Jan 10, 2021·Gastroenterology·Catherine Le BerreUNKNOWN SPIRIT-IOIBD study group

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