Changes in the level of serum high-temperature requirement A1 (HtrA1) during pregnancy and its relationship to preeclampsia

Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy
Lu ZongChunfang Li

Abstract

To investigate the expression and changes of high-temperature requirement A1 (HtrA1) during pregnancy and the use of this value in predicting preeclampsia. Serum samples were collected from pregnant mothers at different gestational weeks, and double-antibody sandwich enzyme-linked immunosorbent assay was employed to describe the changes in HtrA1 in serum during pregnancy. (i) In Xi'an area of China, the incidence of preeclampsia was 4.95%, including 0.85% of early-onset type and 4.10% of late-onset type; (ii) the HtrA1 showed a lognormal distribution during pregnancy in the maternal serum, with the peak at 17-20 weeks of pregnancy; (iii) the HtrA1 levels in preeclampsia mothers peaked at 13-16 weeks of pregnancy, followed by acute decline until 21-24 weeks, then remained stable; (iv) the HtrA1 levels in preeclampsia mothers were higher than the control group in 13-16 weeks and lower than that in 21-24 weeks (p < 0.05); (v) the criteria using lgHtrA1 level at 1.684 during 13-16 weeks of pregnancy could predict hypertension disorders complicating pregnancy (HDCP) with sensitivity of 62.1% and specificity of 53.7%. This could be improved to 85 and 83%, respectively, when combined with body mass index as well as education backgroun...Continue Reading

References

Nov 1, 2002·Molecular Cell·Tim ClausenMichael Ehrmann
Apr 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guiying NieLois A Salamonsen
Oct 31, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Guiying NieLois A Salamonsen
Oct 29, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R AkolekarK H Nicolaides
Oct 22, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Paolo MeloniLuciano Izzo

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Citations

Nov 21, 2015·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Wei ChenHongyou Wang
Sep 26, 2015·International Journal of Molecular Sciences·Pensée WuJohannes J Duvekot
May 23, 2014·Biochemistry·Michael W RisørJan J Enghild
Jun 1, 2017·Paediatric and Perinatal Epidemiology·Rupa Basu
Feb 19, 2021·Placenta·Sasha SkinnerFabricio da Silva Costa
Apr 30, 2021·Tissue & Cell·Sonia FantoneGiovanni Tossetta

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